about
Comparative Characterization of the Leaf Tissue of Physalis alkekengi and Physalis peruviana Using RNA-seq and Metabolite ProfilingGinkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core StructureContribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB ActivationFocused library with a core structure extracted from natural products and modified: application to phosphatase inhibitors and several biochemical findings.Mimicking/extracting structure and functions of natural products: synthetic approaches that address unexplored needs in chemical biology.Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast.Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.Synthesis of the Right-Side Structure of Type B PhysalinsRE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells.Rational Design and Synthesis of [5]Helicene-Derived Phosphine Ligands and Their Application in Pd-Catalyzed Asymmetric Reactions.Design, synthesis, and structure-activity relationship of new isobenzofuranone ligands of protein kinase C.Evaluation of series of isobenzofuranone dimers as PKCalpha ligands: implication for the distance between the two ligand binding sites.Synthesis of the DFGH ring system of type B physalins: highly oxygenated, cage-shaped molecules.CDC25A-inhibitory RE derivatives bind to pocket adjacent to the catalytic site.Development of bis-unsaturated ester aldehydes as amino-glue probes: sequential double azaelectrocyclization as a promising strategy for bioconjugation.Stereocontrolled and convergent entry to CF2-sialosides: synthesis of CF2-linked ganglioside GM4.Synthesis and preliminary biological evaluation of truncated zoanthenol analogues.Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes.A new carbamidemethyl-linked lanthanoid chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells.Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation.Thienyl-Substituted α-Ketoamide: A Less Hydrophobic Reactive Group for Photo-Affinity Labeling.Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-AssemblyReactions of Carbonyl Compounds with Phosphorus Ylide Generated from Tribromofluoromethane and Tris(dimethylamino)phosphineKinetically Controlled One-Pot Formation of DEFGH-Rings of Type B Physalins through Domino-Type TransformationsSynthesis ofCH2-Linked α(2,3)Sialylgalactose Analogue: On the Stereoselectivity of the Key Ireland-Claisen RearrangementUnexpected Diels–Alder/Carbonyl-ene Cascade toward the Biomimetic Synthesis of ChloropupukeananinDesign and synthesis of protein kinase Cα activators based on ‘out of pocket’ interactionsSynthesis of polyunsaturated fatty acid-containing glucuronosyl-diacylglycerol through direct glycosylationConstruction of the benzylic quaternary carbon center of zoanthenol by intramolecular Mizoroki-Heck reaction of enoneImportance of interaction between C1 domain and lipids in protein kinase C alpha activation: hydrophobic side chain direction in isobenzofuranone ligands controls enzyme activation levelEnantioselective synthesis of the fully functionalized ABC ring of zoanthenolSynthesis of CH2-linked α-galactosylceramide and its glucose analogues through glycosyl radical-mediated direct C-glycosylationSynthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor AntagonistsSynthesis of CH2-Linked α(1,6)-Disaccharide Analogues by α-Selective Radical Coupling C-GlycosylationDevelopment of Turn-On Probes for Acids Triggered by Aromaticity Enhancement Using Tricyclic Amidine DerivativesEffects of Substituents on the Properties of Metal-Free MRI Contrast AgentsSynthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation-Inhibitory Activity
P50
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P50
description
onderzoeker
@nl
researcher ORCID ID = 0000-0003-3420-555X
@en
name
Go Hirai
@ast
Go Hirai
@en
Go Hirai
@es
Go Hirai
@nl
type
label
Go Hirai
@ast
Go Hirai
@en
Go Hirai
@es
Go Hirai
@nl
prefLabel
Go Hirai
@ast
Go Hirai
@en
Go Hirai
@es
Go Hirai
@nl
P106
P1153
57195276198
7004302621
P31
P496
0000-0003-3420-555X