about
There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseasesα-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP productionMitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson's Disease.ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.ER-mitochondria signaling regulates autophagyThe ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy.The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activityLMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains
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description
onderzoeker
@nl
researcher ORCID ID = 0000-0002-2388-8327
@en
name
Patricia Gomez-Suaga
@ast
Patricia Gomez-Suaga
@en
Patricia Gomez-Suaga
@es
Patricia Gomez-Suaga
@nl
type
label
Patricia Gomez-Suaga
@ast
Patricia Gomez-Suaga
@en
Patricia Gomez-Suaga
@es
Patricia Gomez-Suaga
@nl
prefLabel
Patricia Gomez-Suaga
@ast
Patricia Gomez-Suaga
@en
Patricia Gomez-Suaga
@es
Patricia Gomez-Suaga
@nl
P106
P1153
53979657900
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0000-0002-2388-8327