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Purified E255L Mutant SERCA1a and Purified PfATP6 Are Sensitive to SERCA-type Inhibitors but Insensitive to ArtemisininsCrystal structure of the sodium–potassium pumpEffect of Hailey-Hailey Disease mutations on the function of a new variant of human secretory pathway Ca2+/Mn2+-ATPase (hSPCA1)Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analysesP4-ATPases as Phospholipid Flippases-Structure, Function, and EnigmasSERCA mutant E309Q binds two Ca2+ions but adopts a catalytically incompetent conformationCrystal Structure of the Vanadate-Inhibited Ca(2+)-ATPaseIdentification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca2+ATPase 3 geneNeurological disease mutations of α3 Na+,K+-ATPase: Structural and functional perspectives and rescue of compromised function.A combined zinc/cadmium sensor and zinc/cadmium export regulator in a heavy metal pump.Critical roles of interdomain interactions for modulatory ATP binding to sarcoplasmic reticulum Ca2+-ATPaseMutational analysis of the conserved TGES loop of sarcoplasmic reticulum Ca2+-ATPase.Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2The role of domain: domain interactions versus domain: water interactions in the coarse-grained simulations of the E1P to E2P transitions in Ca-ATPase (SERCA).Roles of transmembrane segment M1 of Na+,K+-ATPase and Ca2-ATPase, the gatekeeper and the pivot.The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations.The C terminus of Na+,K+-ATPase controls Na+ affinity on both sides of the membrane through Arg935.P-type ATPases as drug targets: tools for medicine and science.Arginine substitution of a cysteine in transmembrane helix M8 converts Na+,K+-ATPase to an electroneutral pump similar to H+,K+-ATPaseCritical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2.A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps.Monomer-oligomer equilibrium of sarcoplasmic reticulum Ca-ATPase and the role of subunit interaction in the Ca2+ pump mechanism.Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis.Overview: subunit interaction and conformational states. Ca-ATPase and Na,K-ATPase compared.Rescue of Na+ affinity in aspartate 928 mutants of Na+,K+-ATPase by secondary mutation of glutamate 314.Crystal structure of D351A and P312A mutant forms of the mammalian sarcoplasmic reticulum Ca(2+) -ATPase reveals key events in phosphorylation and Ca(2+) release.Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.Structure-function relationships of cation translocation by Ca(2+)- and Na+, K(+)-ATPases studied by site-directed mutagenesis.Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses.Determination of the ATP Affinity of the Sarcoplasmic Reticulum Ca(2+)-ATPase by Competitive Inhibition of [γ-(32)P]TNP-8N3-ATP Photolabeling.Dissection of the functional domains of the sarcoplasmic reticulum Ca(2+)-ATPase by site-directed mutagenesis.Mutational analysis of Glu771 of the Ca(2+)-ATPase of sarcoplasmic reticulum. Effect of positive charge on dephosphorylation.Amino acids Asn796 and Thr799 of the Ca(2+)-ATPase of sarcoplasmic reticulum bind Ca2+ at different sites.Functional consequences of alterations to hydrophobic amino acids located in the M4 transmembrane sector of the Ca(2+)-ATPase of sarcoplasmic reticulum.Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates.Functional consequences of alterations to Gly310, Gly770, and Gly801 located in the transmembrane domain of the Ca(2+)-ATPase of sarcoplasmic reticulum.Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease.Kinetic characterization of the normal and detergent-perturbed reaction cycles of the sarcoplasmic reticulum calcium pump. Rate-limiting step(s) under different conditions.Roles of Leu249, Lys252, and Leu253 in membrane segment M3 of sarcoplasmic reticulum Ca2+-ATPase in control of Ca2+ migration and long-range intramolecular communication.Mutagenesis of residues involved in control of the Ca2+ entry pathway and conformational changes associated with Ca2+ binding in the SR Ca2+-ATPase.
P50
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P50
description
researcher ORCID ID = 0000-0003-0654-4300
@en
wetenschapper
@nl
name
Jens Peter Andersen
@ast
Jens Peter Andersen
@en
Jens Peter Andersen
@es
Jens Peter Andersen
@nl
type
label
Jens Peter Andersen
@ast
Jens Peter Andersen
@en
Jens Peter Andersen
@es
Jens Peter Andersen
@nl
prefLabel
Jens Peter Andersen
@ast
Jens Peter Andersen
@en
Jens Peter Andersen
@es
Jens Peter Andersen
@nl
P106
P214
6031149108476868780004
P31
P496
0000-0003-0654-4300