about
Mice Deficient in AKAP13 (BRX) Are Osteoporotic and Have Impaired OsteogenesisAn MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature.Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasionOsteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse.Constitutive expression of Gsα(R201C) in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history.MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D.WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling.Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption.Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMPMT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix.uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion.MT1-MMP-dependent, apoptotic remodeling of unmineralized cartilage: a critical process in skeletal growthMatrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processesA regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formationMT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells.A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream.MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny.MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis.Biglycan modulates angiogenesis and bone formation during fracture healingDimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells.Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia.MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.Btbd7 is essential for region-specific epithelial cell dynamics and branching morphogenesis in vivo.The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone.Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation.Membrane type 1 matrix metalloproteinase is necessary for distal airway epithelial repair and keratinocyte growth factor receptor expression after acute injury.Membrane-type 1 matrix metalloproteinase is required for normal alveolar development.MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnoverGelatinase A (MMP-2) activation by skin fibroblasts: dependence on MT1-MMP expression and fibrillar collagen formOn the role of MT1-MMP, a matrix metalloproteinase essential to collagen remodeling, in murine molar eruption and root growthMT1-MMP is required for efficient tumor dissemination in experimental metastatic diseaseGNAS transcripts in skeletal progenitors: evidence for random asymmetric allelic expression of Gs alphaReplicons of a Rodent Hepatitis C Model Virus Permit Selection of Highly Permissive CellsFibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo
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description
onderzoeker
@nl
researcher ORCID ID = 0000-0002-4472-3257
@en
name
Kenn Holmbeck
@ast
Kenn Holmbeck
@en
Kenn Holmbeck
@es
Kenn Holmbeck
@nl
type
label
Kenn Holmbeck
@ast
Kenn Holmbeck
@en
Kenn Holmbeck
@es
Kenn Holmbeck
@nl
prefLabel
Kenn Holmbeck
@ast
Kenn Holmbeck
@en
Kenn Holmbeck
@es
Kenn Holmbeck
@nl
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P1153
6602337156
P31
P496
0000-0002-4472-3257