Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs
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Role of beta3-adrenergic receptors in the action of a tumour lipid mobilizing factorRenaissance of brown adipose tissue research: integrating the old and newPeriaortic brown adipose tissue as a major determinant of [¹⁸F]-fluorodeoxyglucose vascular uptake in atherosclerosis-prone, apoE-/- miceCardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man.Beta-adrenoreceptors in rat brown adipose tissue: proportions of beta 1- and beta 2-subtypesDirect binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation.Longitudinal trends and subgroup analysis in publication patterns for preclinical data of newly approved drugs.CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis.The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation.Antiobesity pharmacotherapy in the management of type 2 diabetes.A classification study of human β₃-adrenergic receptor agonists using BCUT descriptors.Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene.Hierarchical virtual screening: identification of potential high-affinity and selective β(3)-adrenergic receptor agonists.Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered.Molecular cloning of a human beta 3-adrenergic receptor cDNA.Discovery history and clinical development of mirabegron for the treatment of overactive bladder and urinary incontinence.Characterization of beta 1- and beta 3-adrenoceptors in intact brown adipocytes of the rat.Atypical beta-adrenoceptors in the rat isolated common carotid arteryPotentiation of the anti-obesity effect of the selective beta 3-adrenoceptor agonist BRL 35135 in obese Zucker rats by exercise.Vagus nerve stimulation increases energy expenditure: relation to brown adipose tissue activity.Insulin sensitisation in the treatment of Type 2 diabetes.Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the alpha- and beta-subtypes.ICI D7114 a novel selective beta-adrenoceptor agonist selectively stimulates brown fat and increases whole-body oxygen consumptionEvidence for an atypical, or beta 3-adrenoceptor in ferret tracheal epitheliumComparison of the profiles of agonists as stimulants of the beta 3-adrenoceptor in vitro with their gastroprotective effects in the conscious rat.Expression of beta 3-adrenoceptor mRNA in rat tissues.Differences between the third cardiac beta-adrenoceptor and the colonic beta 3-adrenoceptor in the rat.Receptor for catecholamines responding to catechol which potentiates voltage-dependent calcium current in single cells from guinea-pig taenia caeciMediation of most atypical effects by species homologues of the beta 3-adrenoceptor.Characteristics of cyanopindolol analogues active at the beta 3-adrenoceptor in rat ileumIn vitro inhibition of intestinal motility by phenylethanolaminotetralines: evidence of atypical beta-adrenoceptors in rat colon.Evidence that an atypical beta-adrenoceptor mediates the inhibition of spontaneous rhythmical contractions of rabbit isolated jejunum induced by ritodrine and salbutamol.Activation of β3-adrenoceptors increases in vivo free fatty acid uptake and utilization in brown but not white fat depots in high-fat-fed rats.Challenges in β(3)-Adrenoceptor Agonist Drug DevelopmentCharacterization of propranolol-resistant (-)-[125I]-cyanopindolol binding sites in rat soleus muscle.Evaluation of ICI D7114, a putative stimulant of brown adipocytes, on histamine-contracted guinea-pig ileum.Ligand binding properties of putative beta 3-adrenoceptors compared in brown adipose tissue and in skeletal muscle membranesEvidence for a functional beta 3-adrenoceptor in man.
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Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в травні 1984
@uk
name
Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs
@en
Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs
@nl
type
label
Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs
@en
Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs
@nl
prefLabel
Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs
@en
Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs
@nl
P2093
P356
P1433
P1476
Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs
@en
P2093
A T Ainsworth
M A Cawthorne
M V Sennitt
P2888
P304
P356
10.1038/309163A0
P407
P577
1984-05-01T00:00:00Z
P6179
1043911520