Intravenous Infusion of the Novel HNO Donor BMS-986231 Is Associated With Beneficial Inotropic, Lusitropic, and Vasodilatory Properties in 2 Canine Models of Heart Failure

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Intravenous Infusion of the Novel HNO Donor BMS-986231 Is Associated With Beneficial Inotropic, Lusitropic, and Vasodilatory Properties in 2 Canine Models of Heart Failure

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wetenschappelijk artikel

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наукова стаття, опублікована в жовтні 2018

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Intravenous Infusion of the No ...... Canine Models of Heart Failure

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Intravenous Infusion of the No ...... Canine Models of Heart Failure

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Intravenous Infusion of the No ...... Canine Models of Heart Failure

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Intravenous Infusion of the No ...... Canine Models of Heart Failure

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Intravenous Infusion of the No ...... Canine Models of Heart Failure

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Intravenous Infusion of the No ...... Canine Models of Heart Failure

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P1476

Intravenous Infusion of the No ...... Canine Models of Heart Failure

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Carlos L Del Rio

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Hani N Sabbah

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J Craig Hartman

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John E Reardon

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Kefei Zhang

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P2860

2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries.

Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling.

Nitroxyl (HNO): A novel approach for the acute treatment of heart failure

Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.

Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674.

Nitroxyl enhances myocyte Ca2+ transients by exclusively targeting SR Ca2+-cycling.

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contrib

The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.

Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling.

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625-638

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scholarly article

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10.1016/J.JACBTS.2018.07.003

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English

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P478

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2018-10-01T00:00:00Z

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30456334

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6234500

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