USP14 inhibition corrects an model of impaired mitophagy

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USP14 inhibition corrects an model of impaired mitophagy

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scientific article published on 01 November 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в листопаді 2018

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USP14 inhibition corrects an model of impaired mitophagy

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USP14 inhibition corrects an model of impaired mitophagy

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USP14 inhibition corrects an model of impaired mitophagy

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USP14 inhibition corrects an model of impaired mitophagy

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USP14 inhibition corrects an model of impaired mitophagy

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USP14 inhibition corrects an model of impaired mitophagy

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P1476

USP14 inhibition corrects an in vivo model of impaired mitophagy

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P2093

Aleksandar Rakovic

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Christine Klein

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Elena Marchesan

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Federico Caicci

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Joy Chakraborty

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Sophia von Stockum

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Vanni Ferrari

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P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

Autophagosomes form at ER-mitochondria contact sites

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e9014

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scholarly article

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10.15252/EMMM.201809014

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English

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P478

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Luigi Bubacco

Angelo Antonini

Elena Ziviani

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2018-11-01T00:00:00Z

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30249595

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P921

molecular medicine

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6220287

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