Nonclinical safety assessment of a human interleukin-22FC IG fusion protein demonstrates in vitro to in vivo and cross-species translatability

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Nonclinical safety assessment of a human interleukin-22FC IG fusion protein demonstrates in vitro to in vivo and cross-species translatability

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scientific article published on 15 November 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в листопаді 2018

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name

Nonclinical safety assessment ...... cross-species translatability

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Nonclinical safety assessment ...... cross-species translatability

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Item

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Nonclinical safety assessment ...... cross-species translatability

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Nonclinical safety assessment ...... cross-species translatability

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Nonclinical safety assessment ...... cross-species translatability

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Nonclinical safety assessment ...... cross-species translatability

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Nonclinical safety assessment ...... cross-species translatability

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Ann Herman

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Annemarie Lekkerkerker

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Brandon Harder

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Dimitry M. Danilenko

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Donna W. Lee

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Eric G. Stefanich

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Estelle Doudement

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Jeff Lutman

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Julie Rae

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Rama Pai

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P2860

Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R

IL-22 increases the innate immunity of tissues

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.

γδ T cells protect against lung fibrosis via IL-22.

In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression.

IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues.

IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice

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e00434

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scholarly article

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10.1002/PRP2.434

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2018-11-15T00:00:00Z

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30464842

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interleukin

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6238097

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