about
Dynamic functions of RhoA in tumor cell migration and invasionIntegrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasinIntegrin α6β4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation.Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer.Integrin laminin receptors and breast carcinoma progression.LPA, HGF, and EGF utilize distinct combinations of signaling pathways to promote migration and invasion of MDA-MB-231 breast carcinoma cellsUse of synthetic isoprenoids to target protein prenylation and Rho GTPases in breast cancer invasionClinical significance of the integrin α6β4 in human malignancies.CD151 represses mammary gland development by maintaining the niches of progenitor cells.Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cellsIntegrin α6β4 Promotes Autocrine Epidermal Growth Factor Receptor (EGFR) Signaling to Stimulate Migration and Invasion toward Hepatocyte Growth Factor (HGF).Upregulation and redistribution of integrin alpha6beta4 expression occurs at an early stage in pancreatic adenocarcinoma progressionCoupling S100A4 to Rhotekin alters Rho signaling output in breast cancer cells.Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activationS100A4 drives non-small cell lung cancer invasion, associates with poor prognosis, and is effectively targeted by the FDA-approved anti-helminthic agent niclosamideInhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer.Src kinase pathway is involved in NFAT5-mediated S100A4 induction by hyperosmotic stress in colon cancer cells.LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells.Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways.Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-delta downstream of the Rho/ROK pathway.The role of protein kinase D in neurotensin secretion mediated by protein kinase C-alpha/-delta and Rho/Rho kinase.Integrin α6β4 Upregulates Amphiregulin and Epiregulin through Base Excision Repair-Mediated DNA Demethylation and Promotes Genome-wide DNA Hypomethylation.Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A.Integrin β4 is a controversial target for non-small cell lung cancer-reply.Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistanceUse of pseudosubstrate affinity to measure active protein kinase AS100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2Building a Cancer Education Program in the Modern Era: Lessons from Stone SoupN-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signalsAdjuvant Treatment of Triple-Negative Metaplastic Breast Cancer With Weekly Paclitaxel and Platinum Chemotherapy: Retrospective Case Review From a Single Institution
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P50
description
researcher ORCID ID = 0000-0002-1088-9734
@en
wetenschapper
@nl
name
Kathleen L O'Connor
@ast
Kathleen L O'Connor
@en
Kathleen L O'Connor
@es
Kathleen L O'Connor
@nl
type
label
Kathleen L O'Connor
@ast
Kathleen L O'Connor
@en
Kathleen L O'Connor
@es
Kathleen L O'Connor
@nl
prefLabel
Kathleen L O'Connor
@ast
Kathleen L O'Connor
@en
Kathleen L O'Connor
@es
Kathleen L O'Connor
@nl
P108
P1153
7203002559
P31
P496
0000-0002-1088-9734