about
How best to identify chromosomal interactions: a comparison of approaches.Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity.Genetic dissection of the α-globin super-enhancer in vivo.Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemiaHoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis.Sasquatch: predicting the impact of regulatory SNPs on transcription factor binding from cell- and tissue-specific DNase footprints.Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domainsA tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactionsReconstruction of the global neural crest gene regulatory network in vivo: Supplemental_MaterialAn integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesisA revised model for promoter competition based on multi-way chromatin interactions at the α-globin locusThe bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and XistDOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylationDynamics of the 4D genome during in vivo lineage specification and differentiation
P50
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P50
description
researcher ORCID ID = 0000-0002-8955-7256
@en
wetenschapper
@nl
name
Jim R Hughes
@ast
Jim R Hughes
@en
Jim R Hughes
@nl
type
label
Jim R Hughes
@ast
Jim R Hughes
@en
Jim R Hughes
@nl
prefLabel
Jim R Hughes
@ast
Jim R Hughes
@en
Jim R Hughes
@nl
P31
P496
0000-0002-8955-7256