about
Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleedingA unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia veraHeterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patientsMYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.The abnormal proplatelet formation in MYH9-related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition.Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivationMechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets.A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene.Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.Progress in understanding the diagnosis and molecular genetics of macrothrombocytopenias.P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors.Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint.p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging.Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro.Regulation of megakaryocyte maturation and platelet formation.MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9.Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients.RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization.Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.Immunophenotypic study of atypical lymphocytes. Generated in peripheral blood and spleen of nude mice After MHV-72 infection.Eltrombopag, a potent stimulator of megakaryopoiesis.Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.Concomitant germ-line RUNX1 and acquired ASXL1 mutations in a T-cell acute lymphoblastic leukemia.Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation.Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect.Megakaryocyte and polyploidization.Mutations of the integrin αIIb/β3 intracytoplasmic salt bridge cause macrothrombocytopenia and enlarged platelet α-granules.A new heterozygous mutation in GP1BA gene responsible for macrothrombocytopenia.The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis.Developmental changes in human megakaryopoiesis.ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach.Clinic, pathogenic mechanisms and drug testing of two inherited thrombocytopenias, ANKRD26-related Thrombocytopenia and MYH9-related diseases.
P50
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P50
description
researcher ORCID ID = 0000-0001-8846-5299
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wetenschapper
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name
Hana Raslova
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Hana Raslova
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Hana Raslova
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Hana Raslova
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Hana Raslova
@nl
type
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Hana Raslova
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Hana Raslova
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Hana Raslova
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Hana Raslova
@fr
Hana Raslova
@nl
prefLabel
Hana Raslova
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Hana Raslova
@en
Hana Raslova
@es
Hana Raslova
@fr
Hana Raslova
@nl
P214
P21
P214
P31
P496
0000-0001-8846-5299
P7859
viaf-212235825