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TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive HematopoiesisCaspase-3 cleaved p65 fragment dampens NF-κB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interactionSam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ationMetalloprotease NleC suppresses host NF-κB/inflammatory responses by cleaving p65 and interfering with the p65/RPS3 interactionIdentification of an N-terminal truncation of the NF-κB p65 subunit that specifically modulates ribosomal protein S3-dependent NF-κB gene expression.Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells.Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation.Ultrasound imaging of splenomegaly as a proxy to monitor colon tumor development in Apc(min716/+) mice.CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer.Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice.
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onderzoeker
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researcher ORCID ID = 0000-0003-2424-8011
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Xin Sun
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Xin Sun
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Xin Sun
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Xin Sun
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Xin Sun
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Xin Sun
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0000-0003-2424-8011