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Systematic production of inactivating and non-inactivating suppressor mutations at the relA locus that compensate the detrimental effects of complete spot loss and affect glycogen content in Escherichia coliModelling and analysis of central metabolism operating regulatory interactions in salt stress conditions in a L-carnitine overproducing E. coli strain.Culture collections and biochemistry.Role of central metabolism in the osmoadaptation of the halophilic bacterium Chromohalobacter salexigens.Production of L-carnitine by secondary metabolism of bacteriaTranscriptional regulation differs in affected facioscapulohumeral muscular dystrophy patients compared to asymptomatic related carriers.Ectoines in cell stress protection: uses and biotechnological production.Regulation of bacterial physiology by lysine acetylation of proteins.Protein acetylation affects acetate metabolism, motility and acid stress response in Escherichia coliAcetate metabolism regulation in Escherichia coli: carbon overflow, pathogenicity, and beyond.Understanding the interplay of carbon and nitrogen supply for ectoines production and metabolic overflow in high density cultures of Chromohalobacter salexigens.Acquisition of MDR phenotype by leukemic cells is associated with increased caspase-3 activity and a collateral sensitivity to cold stress.Metabolomic responses in caged clams, Ruditapes decussatus, exposed to agricultural and urban inputs in a Mediterranean coastal lagoon (Mar Menor, SE Spain).Lycopene overproduction and in situ extraction in organic-aqueous culture systems using a metabolically engineered Escherichia coli.Modeling of the biotransformation of crotonobetaine into L-(-)-carnitine by Escherichia coli strains.Modeling, optimization and experimental assessment of continuous L-(-)-carnitine production by Escherichia coli cultures.An insight into the role of phosphotransacetylase (pta) and the acetate/acetyl-CoA node in Escherichia coli.Contribution of RpoS to metabolic efficiency and ectoines synthesis during the osmo- and heat-stress response in the halophilic bacterium Chromohalobacter salexigens.Quantitative analysis of the dynamic signaling pathway involved in the cAMP mediated induction of l-carnitine biosynthesis in E. coli cultures.Model identification in presence of incomplete information by generalized principal component analysis: application to the common and differential responses of Escherichia coli to multiple pulse perturbations in continuous, high-biomass density cultLipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis.Effect of salt stress on crotonobetaine and D(+)-carnitine biotransformation into L(-)-carnitine by resting cells of Escherichia coli.Thermal biology of Phymaturus lizards: evolutionary constraints or lack of environmental variation?Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas.Design of metabolic engineering strategies for maximizing L-(-)-carnitine production by Escherichia coli. Integration of the metabolic and bioreactor levels.Role of betaine:CoA ligase (CaiC) in the activation of betaines and the transfer of coenzyme A in Escherichia coli.Impairing and monitoring glucose catabolite repression in L-carnitine biosynthesis.Characterization of CobB kinetics and inhibition by nicotinamide.An acetylatable lysine controls CRP function in E. coli.Redirecting metabolic fluxes through cofactor engineering: Role of CoA-esters pool during L(-)-carnitine production by Escherichia coli.Insights into metabolic osmoadaptation of the ectoines-producer bacterium Chromohalobacter salexigens through a high-quality genome scale metabolic model.Attenuated JNK signaling in multidrug-resistant leukemic cells. Dual role of MAPK in cell survival.Role of energetic coenzyme pools in the production of L-carnitine by Escherichia coli.Bioequivalence study of 2 orodispersible formulations of zolmitriptan 5 mg in healthy volunteers.A model that links growth and secondary metabolite production in plant cell suspension cultures.Collateral sensitivity to cold stress and differential BCL-2 family expression in new daunomycin-resistant lymphoblastoid cell lines.GlgS, described previously as a glycogen synthesis control protein, negatively regulates motility and biofilm formation in Escherichia coli.cAMP-CRP co-ordinates the expression of the protein acetylation pathway with central metabolism in Escherichia coli.Acetate scavenging activity in Escherichia coli: interplay of acetyl-CoA synthetase and the PEP-glyoxylate cycle in chemostat cultures.Enzymatic cycling assay for D-carnitine determination
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P50
description
researcher ORCID ID = 0000-0003-3254-1736
@en
wetenschapper
@nl
name
Manuel Canovas
@ast
Manuel Canovas
@en
Manuel Canovas
@es
Manuel Canovas
@nl
type
label
Manuel Canovas
@ast
Manuel Canovas
@en
Manuel Canovas
@es
Manuel Canovas
@nl
prefLabel
Manuel Canovas
@ast
Manuel Canovas
@en
Manuel Canovas
@es
Manuel Canovas
@nl
P106
P21
P31
P496
0000-0003-3254-1736