about
Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine ModelsCrystal structure and DNA repair activities of the AP endonuclease from Leishmania majorStructural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinaseSynthesis and Evaluation of α-Thymidine Analogues as Novel AntimalarialsCell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma bruceiDiscovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural ProductsThe NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cellsDesign, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase.New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii.High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major.Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.In vitro antiplasmodial and cytotoxic activities of asymmetrical pyridinium derivatives.Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype.Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds.Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coliNovel inhibitors of Trypanosoma cruzi dihydrofolate reductase.The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.Insights into the role of endonuclease V in RNA metabolism in Trypanosoma brucei.Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids.Novel inhibitors of Leishmanial dihydrofolate reductase.Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.Characterization of deoxyuridine 5'-triphosphate nucleotidohydrolase from Trypanosoma cruzi.Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.A novel calcium-dependent soluble inorganic pyrophosphatase from the trypanosomatid Leishmania major.dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.Intracellular location of the early steps of the isoprenoid biosynthetic pathway in the trypanosomatids Leishmania major and Trypanosoma brucei.Evaluation of azasterols as anti-parasitics.Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide.Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei.Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase.
P50
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P50
description
onderzoeker
@nl
researcher ORCID ID = 0000-0001-7681-4471
@en
name
Luis Miguel Ruiz-Pérez
@ast
Luis Miguel Ruiz-Pérez
@en
Luis Miguel Ruiz-Pérez
@es
Luis Miguel Ruiz-Pérez
@nl
type
label
Luis Miguel Ruiz-Pérez
@ast
Luis Miguel Ruiz-Pérez
@en
Luis Miguel Ruiz-Pérez
@es
Luis Miguel Ruiz-Pérez
@nl
prefLabel
Luis Miguel Ruiz-Pérez
@ast
Luis Miguel Ruiz-Pérez
@en
Luis Miguel Ruiz-Pérez
@es
Luis Miguel Ruiz-Pérez
@nl
P106
P1153
7004693499
P21
P31
P496
0000-0001-7681-4471