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Structural characteristics of the nonallosteric human cytosolic malic enzymeDeterminants of the dual cofactor specificity and substrate cooperativity of the human mitochondrial NAD(P)+-dependent malic enzyme: functional roles of glutamine 362Differentiation of the slow-binding mechanism for magnesium ion activation and zinc ion inhibition of human placental alkaline phosphataseVimentin is involved in peptidylarginine deiminase 2-induced apoptosis of activated Jurkat cells.Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme.Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4.Critical factors governing the difference in antizyme-binding affinities between human ornithine decarboxylase and antizyme inhibitor.Minimal antizyme peptide fully functioning in the binding and inhibition of ornithine decarboxylase and antizyme inhibitor.Determinants of nucleotide-binding selectivity of malic enzymeFunctional roles of the dimer-interface residues in human ornithine decarboxylase.Determinants of the differential antizyme-binding affinity of ornithine decarboxylaseBiophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme.Functional roles of the non-catalytic calcium-binding sites in the N-terminal domain of human peptidylarginine deiminase 4A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)+-dependent malic enzyme (ME2) and induces cellular senescence.Structural basis of antizyme-mediated regulation of polyamine homeostasis.Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor.A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22Critical factors determining dimerization of human antizyme inhibitor.Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4.Ornithine decarboxylase interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-kappaB.Long-range interaction between the enzyme active site and a distant allosteric site in the human mitochondrial NAD(P)+-dependent malic enzyme.Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion.Characterization of the functional role of allosteric site residue Asp102 in the regulatory mechanism of human mitochondrial NAD(P)+-dependent malate dehydrogenase (malic enzyme).Metal-Induced reversible structural interconversion of human mitochondrial NAD(P)+-dependent malic enzyme.Dual roles of Lys(57) at the dimer interface of human mitochondrial NAD(P)+-dependent malic enzyme.Influential factor contributing to the isoform-specific inhibition by ATP of human mitochondrial NAD(P)+-dependent malic enzyme: functional roles of the nucleotide binding site Lys346.Effects of structural analogues of the substrate and allosteric regulator of the human mitochondrial NAD(P)+-dependent malic enzyme.Functional role of fumarate site Glu59 involved in allosteric regulation and subunit-subunit interaction of human mitochondrial NAD(P)+-dependent malic enzyme.Engineering of the cofactor specificities and isoform-specific inhibition of malic enzyme.Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells.Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells.Equilibrium protein folding-unfolding process involving multiple intermediates.Antizyme, a natural ornithine decarboxylase inhibitor, induces apoptosis of haematopoietic cells through mitochondrial membrane depolarization and caspases' cascade.Slow Binding of Metal Ions to Pigeon Liver Malic Enzyme: A General Case†Structural variation manipulates the differential oxidative susceptibility and conformational stability of apolipoprotein E isoformsInhibitory effect of magnesium ion on the human placental alkaline phosphatase-catalyzed reaction in a reverse micellar systemBiphasic denaturation of human placental alkaline phosphatase in guanidinium chlorideThe functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cellsCritical Factors in Human Antizymes that Determine the Differential Binding, Inhibition, and Degradation of Human Ornithine DecarboxylaseFunctional Roles of Metabolic Intermediates in Regulating the Human Mitochondrial NAD(P)+-Dependent Malic Enzyme
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P50
description
researcher ORCID ID = 0000-0003-0180-1822
@en
wetenschapper
@nl
name
Hui-Chih Hung
@ast
Hui-Chih Hung
@en
Hui-Chih Hung
@es
Hui-Chih Hung
@nl
type
label
Hui-Chih Hung
@ast
Hui-Chih Hung
@en
Hui-Chih Hung
@es
Hui-Chih Hung
@nl
prefLabel
Hui-Chih Hung
@ast
Hui-Chih Hung
@en
Hui-Chih Hung
@es
Hui-Chih Hung
@nl
P106
P31
P496
0000-0003-0180-1822