about
A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cellsCharacterization of integrin engagement during defined human embryonic stem cell cultureDirected evolution of adeno-associated virus to an infectious respiratory virusSubstrate modulus directs neural stem cell behaviorComputational models of the Notch network elucidate mechanisms of context-dependent signalingMicroelastic mapping of the rat dentate gyrusImaging light responses of foveal ganglion cells in the living macaque eye.Biogenic gas nanostructures as ultrasonic molecular reportersEvidence-based screening criteria for retinopathy of prematurity: natural history data from the CRYO-ROP and LIGHT-ROP studies.Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform.Selection of novel vesicular stomatitis virus glycoprotein variants from a peptide insertion library for enhanced purification of retroviral and lentiviral vectorsAdvanced targeting strategies for murine retroviral and adeno-associated viral vectors.High-throughput, library-based selection of a murine leukemia virus variant to infect nondividing cellsEngineering adeno-associated virus for one-step purification via immobilized metal affinity chromatography.Library selection and directed evolution approaches to engineering targeted viral vectors.Designer gene delivery vectors: molecular engineering and evolution of adeno-associated viral vectors for enhanced gene transferMolecular engineering of viral gene delivery vehiclesDNA shuffling of adeno-associated virus yields functionally diverse viral progenyMolecular evolution of adeno-associated virus for enhanced glial gene delivery.Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous.Exploiting bacterial peptide display technology to engineer biomaterials for neural stem cell cultureDefined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System.Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery.Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: a model system to study neurotoxicity in Alzheimer's disease.Adeno-Associated Virus-Mediated Delivery of CRISPR-Cas Systems for Genome Engineering in Mammalian Cells.Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity.Biophysics and dynamics of natural and engineered stem cell microenvironments.The sonic hedgehog signaling system as a bistable genetic switch.Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesisOptogenetic protein clustering and signaling activation in mammalian cells.Molecular characterization of multivalent bioconjugates by size-exclusion chromatography with multiangle laser light scatteringBiophysical regulation of epigenetic state and cell reprogramming.Surface creasing instability of soft polyacrylamide cell culture substratesMagnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast.Nox2 redox signaling maintains essential cell populations in the brain.Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In VivoAAV-mediated, optogenetic ablation of Müller Glia leads to structural and functional changes in the mouse retinaAkt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation.Engineering the surface properties of synthetic gene delivery vectors.Enhanced sialic acid-dependent endocytosis explains the increased efficiency of infection of airway epithelia by a novel adeno-associated virus
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description
researcher ORCID ID = 0000-0002-9625-0121
@en
wetenschapper
@nl
name
David Schaffer
@ast
David Schaffer
@en
David Schaffer
@es
David Schaffer
@nl
type
label
David Schaffer
@ast
David Schaffer
@en
David Schaffer
@es
David Schaffer
@nl
prefLabel
David Schaffer
@ast
David Schaffer
@en
David Schaffer
@es
David Schaffer
@nl
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P21
P31
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0000-0002-9625-0121