about
Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation InhibitorsAn empirical process for the design of high-throughput screening deck filters.Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues.Coupling Laser Diode Thermal Desorption with Acoustic Sample Deposition to Improve Throughput of Mass Spectrometry-Based Screening.Analysis of large peptides by MALDI using a linear quadrupole ion trap with mass range extension.Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.Screening and characterization of reactive compounds with in vitro peptide-trapping and liquid chromatography/high-resolution accurate mass spectrometry.Bioanalysis of acetylcarnitine in cerebrospinal fluid by HILIC-mass spectrometry.Acoustic Sample Deposition MALDI-MS (ASD-MALDI-MS): A Novel Process Flow for Quality Control Screening of Compound Libraries.Ionization sources and mass analyzers in MS imaging.The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy VolunteersRobust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.Advances in mass spectrometry applied to pharmaceutical metabolomics.Beyond classical derivatization: analyte 'derivatives' in the bioanalysis of endogenous and exogenous compounds.The utility of stable isotope labeled (SIL) analogues in the bioanalysis of endogenous compounds by LC-MS applied to the study of bile acids in a metabolomics assay.Extraction, identification, and functional characterization of a bioactive substance from automated compound-handling plastic tips.P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.Application of Cassette Ultracentrifugation Using Non-labeled Compounds and Liquid Chromatography-Tandem Mass Spectrometry Analysis for High-Throughput Protein Binding Determination.Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.Simultaneous bioanalysis of a phosphate prodrug and its parent compound using a multiplexed LC-MS method.Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays.Normalization strategies for metabonomic analysis of urine samples.Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.Synergistic inhibition of Aβ production by combinations of γ-secretase modulators.Stable isotope labeling by amino acids in cell culture-based liquid chromatography-mass spectrometry assay to measure microtubule dynamics in neuronal cell cultures.Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites.Strategy to improve the quantitative LC-MS analysis of molecular ions resistant to gas-phase collision induced dissociation: application to disulfide-rich cyclic peptides.Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development.2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV) (Part 1 - small molecules, peptides and small molecule biomarkers by LCMS).Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy SubjectsAn automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletionApplication of ion trap technology to liquid chromatography/mass spectrometry quantitation of large peptidesLabware additives identified to be selective monoamine oxidase-B inhibitorsAnalysis of L-serine-O-phosphate in cerebrospinal spinal fluid by derivatization-liquid chromatography/mass spectrometryBioanalysis of (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) in rat plasma using derivatization liquid chromatography/mass spectrometryMass spectrometry techniques for qualitative and quantitative analysis of biomarkersAssessing the risk of drug crystallization in vivo
P50
Q28554482-6943059C-5D8F-4CE0-A9C8-3321B9C8DE80Q33244050-ACBBF47C-2E2E-478C-B7FD-6085FDE6E412Q33269196-AB3E8DDC-9519-4D1B-8247-0793FA7B2EB6Q33466235-57995396-F700-4F98-87E5-94AB9E7C8C16Q33523121-A8BCBCB4-854E-49EB-9B6D-83E527C0CC5CQ33944771-74B160FB-E97F-4ADD-AAD2-04C19ED16833Q34091361-11C62654-4DB9-42D9-B2E5-6905E925FD56Q34782133-FF755DC3-226D-44EE-B967-78DBAC6582E0Q35567205-D3CC176B-5CD4-42F1-8FFE-31B8170BE271Q35707506-1D5CAB11-442A-4F01-B1AA-69A69595CC5DQ35825084-8A80A77E-293F-49E9-B27F-39D35C6E2D75Q37062574-6163F9E7-D6C1-4225-BAF7-BEAF2227ACD3Q37062579-C68A91C4-58E1-4BB1-94A3-8F73D3D9C7A1Q37812335-3666A50B-16E2-48F0-957A-D31C1AC1314AQ38953539-1F53BF68-3731-4657-8622-451360B01AFAQ39136891-7C632C8A-4D79-4740-912F-04588B24CE91Q39846998-DD10F822-AC12-4879-B44D-7381295C8731Q39979190-135080C3-F216-4FFF-A019-25E7D2E67C2DQ40787912-FDA5F0CC-0575-4661-9F9E-5E3B588594A8Q40862619-B2D964B2-37BF-4EEE-80E0-52FB12D452DEQ42807057-2912B940-0655-4804-8CB7-C8ADC624B4ACQ44033985-877CF974-52E5-4A6D-956F-164E5CEC2205Q46137413-14BC9D13-21FA-4DAA-9962-3BA2F4153CC1Q46356915-D3429C60-5E1B-4A91-94B6-3CE92952F56EQ48204304-E3F67666-A868-4029-8DB7-B7FEEC7C3C01Q48572930-19F272D0-6F0F-4012-AF52-477CA9C6D85EQ50551234-E830813F-7B11-40CD-9150-71E39B78AC3DQ51037487-230031F6-5B49-422E-99B9-6089F372BE9CQ51132880-8F58D6A4-7246-45F3-B836-6880F030D3A1Q53138251-CD6DF97B-D528-47F6-AD7C-699E450546F0Q58559857-810DCCA9-2446-4718-8335-55F7921FAE46Q80859486-5E586097-FA0C-4D11-8D76-AB9ABE2CF012Q80995638-D00DE5B0-D7C4-4AF6-B59C-576BFD9060DAQ85716707-13C27956-486F-4825-A692-588B596BE9A6Q87305706-841ED129-C0F6-48B4-BB4F-9DAA8F51DF90Q87664236-71806666-FCAB-4F8B-8A6E-F4FCD3BD1FEEQ88188898-C6B1800F-E02D-44A1-913A-62069FB05251Q90558506-D1CFC5FB-161F-418C-91F7-4C0B9525B23B
P50
description
Forscher
@de
chercheur
@fr
investigador
@es
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
研究者
@zh
name
Dieter M Drexler
@ast
Dieter M Drexler
@en
Dieter M Drexler
@es
Dieter M Drexler
@nl
type
label
Dieter M Drexler
@ast
Dieter M Drexler
@en
Dieter M Drexler
@es
Dieter M Drexler
@nl
prefLabel
Dieter M Drexler
@ast
Dieter M Drexler
@en
Dieter M Drexler
@es
Dieter M Drexler
@nl
P1153
6603578485
P31
P496
0000-0003-2877-7973