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Interplay between glutamatergic and GABAergic neurotransmission alterations in cognitive and motor impairment in minimal hepatic encephalopathy.Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy.Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia.Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy.Extracellular Cyclic GMP Modulates Membrane Expression of The GluA1 and GluA2 Subunits of AMPA Receptor in Cerebellum: Molecular Mechanisms Involved.Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats.Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy.In vivo administration of extracellular cGMP normalizes TNF-α and membrane expression of AMPA receptors in hippocampus and spatial reference memory but not IL-1β, NMDA receptors in membrane and working memory in hyperammonemic rats.The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons.Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate ReceptorsSustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathwayHistological Features of Cerebellar Neuropathology in Patients With Alcoholic and Nonalcoholic SteatohepatitisChronic hyperammonemia induces peripheral inflammation that leads to cognitive impairment in rats: reversal by anti-tnfa treatmentPeripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implicationsDifferential role of interleukin-1β in neuroinflammation-induced impairment of spatial and nonspatial memory in hyperammonemic rats
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description
researcher ORCID ID = 0000-0001-6523-2206
@en
wetenschapper
@nl
name
Tiziano Balzano
@ast
Tiziano Balzano
@en
Tiziano Balzano
@es
Tiziano Balzano
@nl
type
label
Tiziano Balzano
@ast
Tiziano Balzano
@en
Tiziano Balzano
@es
Tiziano Balzano
@nl
prefLabel
Tiziano Balzano
@ast
Tiziano Balzano
@en
Tiziano Balzano
@es
Tiziano Balzano
@nl
P1153
56786432500
P31
P496
0000-0001-6523-2206