about
LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activityReelin haploinsufficiency reduces the density of PV+ neurons in circumscribed regions of the striatum and selectively alters striatal-based behaviorsAldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum.Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome.Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease.Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neuronsl-DOPA reverses the impairment of Dentate Gyrus LTD in experimental parkinsonism via β-adrenergic receptors.Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1No apparent transmission of transgenic α-synuclein into nigrostriatal dopaminergic neurons in multiple mouse models.α-Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals.Short-term and long-term plasticity at corticostriatal synapses: implications for learning and memory.Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis.Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.Synaptic dysfunction in Parkinson's disease.Striatum-hippocampus balance: from physiological behavior to interneuronal pathology.Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia.Hippocampal synaptic plasticity, memory, and epilepsy: effects of long-term valproic acid treatment.Intensification of maternal care by double-mothering boosts cognitive function and hippocampal morphology in the adult offspring.Abnormal medial prefrontal cortex connectivity and defective fear extinction in the presymptomatic G93A SOD1 mouse model of ALS.Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition.mTOR inhibitor rapamycin suppresses striatal post-ischemic LTP.Epilepsy-induced abnormal striatal plasticity in Bassoon mutant mice.Acetyl-L-Carnitine selectively prevents post-ischemic LTP via a possible action on mitochondrial energy metabolism.Dopamine-dependent long-term depression is expressed in striatal spiny neurons of both direct and indirect pathways: implications for Parkinson's disease.Rebalance of striatal NMDA/AMPA receptor ratio underlies the reduced emergence of dyskinesia during D2-like dopamine agonist treatment in experimental Parkinson's disease.Altered cortico-striatal synaptic plasticity and related behavioural impairments in reeler mice.Landmark-based but not vestibular-based orientation elicits mossy fiber synaptogenesis in the mouse hippocampus.Reversible inactivation of hippocampus and dorsolateral striatum in C57BL/6 and DBA/2 inbred mice failed to show interaction between memory systems in these genotypes.Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias.Postsynaptic Alteration of NR2A Subunit and Defective Autophosphorylation of alphaCaMKII at Threonine-286 Contribute to Abnormal Plasticity and Morphology of Upper Motor Neurons in Presymptomatic SOD1G93A Mice, a Murine Model for Amyotrophic LateralUnbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian miceIn vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondriaTau deletion reduces plaque-associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's diseaseLoss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's diseaseLongitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second-Generation Amyloid-β Mouse Model
P50
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P50
description
Forscher
@de
chercheur
@fr
investigador
@es
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
研究者
@zh
name
Carmelo Sgobio
@ast
Carmelo Sgobio
@en
Carmelo Sgobio
@es
Carmelo Sgobio
@nl
type
label
Carmelo Sgobio
@ast
Carmelo Sgobio
@en
Carmelo Sgobio
@es
Carmelo Sgobio
@nl
prefLabel
Carmelo Sgobio
@ast
Carmelo Sgobio
@en
Carmelo Sgobio
@es
Carmelo Sgobio
@nl
P1153
11241517000
P21
P31
P496
0000-0002-6282-369X