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Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administrationProbing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteriaTeaching 'old' polymyxins new tricks: new-generation lipopeptides targeting gram-negative 'superbugs'.Activities of colistin- and minocycline-based combinations against extensive drug resistant Acinetobacter baumannii isolates from intensive care unit patients.Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate.A novel polymyxin derivative that lacks the fatty acid tail and carries only three positive charges has strong synergism with agents excluded by the intact outer membranefAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models.Pharmacokinetic/pharmacodynamic investigation of colistin against Pseudomonas aeruginosa using an in vitro model.Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production.Different surface charge of colistin-susceptible and -resistant Acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatmentColistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections.Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A.Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae.Colistin methanesulfonate is an inactive prodrug of colistin against Pseudomonas aeruginosa.Novel rate-area-shape modeling approach to quantify bacterial killing and regrowth for in vitro static time-kill studies.Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway.Insertion sequence ISAba11 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii.Colistin and polymyxin B: peas in a pod, or chalk and cheese?Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactionsSignificant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach.Imaging the distribution of polymyxins in the kidneyPopulation pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patientsMajor pathways of polymyxin-induced apoptosis in rat kidney proximal tubular cells.Melatonin attenuates colistin-induced nephrotoxicity in rats.Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant Pseudomonas aeruginosa at multiple inocula.Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance.Synergistic killing of multidrug-resistant Pseudomonas aeruginosa at multiple inocula by colistin combined with doripenem in an in vitro pharmacokinetic/pharmacodynamic model.Preliminary clinical study of the effect of ascorbic acid on colistin-associated nephrotoxicityColistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosaAntibacterial Low Molecular Weight Cationic Polymers: Dissecting the Contribution of Hydrophobicity, Chain Length and Charge to ActivityStepwise evolution of pandrug-resistance in Klebsiella pneumoniae.Effect of colistin exposure and growth phase on the surface properties of live Acinetobacter baumannii cells examined by atomic force microscopyCell surface hydrophobicity of colistin-susceptible vs resistant Acinetobacter baumannii determined by contact angles: methodological considerations and implicationsInteraction of colistin and colistin methanesulfonate with liposomes: colloidal aspects and implications for formulation.Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoproteinSynergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol.The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic modelCellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes.Pharmacokinetics and pharmacodynamics of 'old' polymyxins: what is new?Drug release from nanomedicines: Selection of appropriate encapsulation and release methodology.
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P50
description
researcher ORCID ID = 0000-0001-7953-8230
@en
name
Jian Li
@ast
Jian Li
@en
Jian Li
@nl
type
label
Jian Li
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Jian Li
@en
Jian Li
@nl
prefLabel
Jian Li
@ast
Jian Li
@en
Jian Li
@nl
P214
58146094210800330918
P31
P496
0000-0001-7953-8230
P7859
lccn-no2016036237