about
Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancerMolecular pathways: IL11 as a tumor-promoting cytokine-translational implications for cancersCritical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosisDistinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transductionGenetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivoGlycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease.Optimal preparation methods for automated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling of low molecular weight proteins and peptides.Enhanced osteoblast proliferation and collagen gene expression by estradiol.Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast CancerQuantitative intratumoural microdistribution and kinetics of (131)I-huA33 antibody in patients with colorectal carcinoma.Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer ProgressionIL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.Non-invasive assessment of the efficacy of new therapeutics for intestinal pathologies using serial endoscopic imaging of live miceSTAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease?c-Myb is required for progenitor cell homeostasis in colonic crypts.IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling.The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells.A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.Modelling COPD in mice.Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantationGenetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis.STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in miceTRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation.Intestinal-specific activatable Myb initiates colon tumorigenesis in mice.An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.Mouse models for gastric cancer: Matching models to biological questions.More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer.Epithelial gp130/Stat3 functions: an intestinal signaling node in health and disease.Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130.Osteoblastlike cells in a serum-free methylcellulose medium form colonies: effects of insulin and insulinlike growth factor I.IL-11 signaling as a therapeutic target for cancer.Targeting JAK kinase in solid tumors: emerging opportunities and challenges.Generation of an inducible mouse model to reversibly silence Stat3.Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.
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description
Forscher
@de
chercheur
@fr
investigador
@es
researcher
@en
հետազոտող
@hy
研究者
@zh
name
Matthias Ernst
@ast
Matthias Ernst
@en
Matthias Ernst
@es
Matthias Ernst
@nl
Matthias Ernst
@pt
type
label
Matthias Ernst
@ast
Matthias Ernst
@en
Matthias Ernst
@es
Matthias Ernst
@nl
Matthias Ernst
@pt
prefLabel
Matthias Ernst
@ast
Matthias Ernst
@en
Matthias Ernst
@es
Matthias Ernst
@nl
Matthias Ernst
@pt
P21
P31
P496
0000-0002-6399-1177