about
Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factorEnhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping.Biophysical approaches promote advances in the understanding of von Willebrand factor processing and function.A biophysical view on von Willebrand factor activation.Efficacious inhibition of Importin α/β-mediated nuclear import of human inositol phosphate multikinase.Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation.The inositol 5-phosphatase SHIP1 is a nucleo-cytoplasmic shuttling protein and enzymatically active in cell nuclei.Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami.Mutual A domain interactions in the force sensing protein von Willebrand factor.Force-sensitive autoinhibition of the von Willebrand factor is mediated by interdomain interactionsHuman inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation.Von Willebrand factor processing.Genetic and Functional Characterization of ADAMTS13 Variants in a Patient Cohort with Upshaw-Schulman Syndrome Investigated in Germany.Platelet-free shear flow assay facilitates analysis of shear-dependent functions of VWF and ADAMTS13.von Willebrand disease type 2A phenotypes IIC, IID and IIE: A day in the life of shear-stressed mutant von Willebrand factorThe von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarctionAdvancing multimer analysis of von Willebrand factor by single-molecule AFM imagingUpshaw-Schulman syndrome-associated ADAMTS13 variants possess proteolytic activity at the surface of endothelial cells and in simulated circulation
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description
researcher ORCID ID = 0000-0003-0416-8233
@en
wetenschapper
@nl
name
Maria A Brehm
@ast
Maria A Brehm
@en
Maria A Brehm
@es
Maria A Brehm
@nl
type
label
Maria A Brehm
@ast
Maria A Brehm
@en
Maria A Brehm
@es
Maria A Brehm
@nl
prefLabel
Maria A Brehm
@ast
Maria A Brehm
@en
Maria A Brehm
@es
Maria A Brehm
@nl
P1153
23099381400
P31
P496
0000-0003-0416-8233