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Discovery of a β-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology.A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands.A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist.Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors.Metabolically stabilized long-circulating PEGylated polyacridine peptide polyplexes mediate hydrodynamically stimulated gene expression in liver.Iterative Reducible Ligation to form Homogeneous Penicillamine Cross-linked Polypeptides.PEG length and chemical linkage controls polyacridine peptide DNA polyplex pharmacokinetics, biodistribution, metabolic stability and in vivo gene expression.A Convergent Synthesis of Homogeneous Reducible Polypeptides.Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist PharmacologStructure⁻Activity Relationships of the Tetrapeptide Ac-His-Arg-(I)DPhe-Tic-NH at the Mouse Melanocortin Receptors: Modification at the (I)DPhe Position Leads to mMC3R Versus mMC4R Selective LigandsChange in surface hardness of enamel by a cola drink and a CPP-ACP pasteSynthesis of homogenous disulfide cross-linked polypeptides by iterative reducible ligationHuman β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin ReceptorsStructure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake
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P50
description
researcher ORCID ID = 0000-0002-8715-6010
@en
wetenschapper
@nl
name
Mark D Ericson
@ast
Mark D Ericson
@en
Mark D Ericson
@es
Mark D Ericson
@nl
type
label
Mark D Ericson
@ast
Mark D Ericson
@en
Mark D Ericson
@es
Mark D Ericson
@nl
prefLabel
Mark D Ericson
@ast
Mark D Ericson
@en
Mark D Ericson
@es
Mark D Ericson
@nl
P31
P496
0000-0002-8715-6010