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ConoServer: updated content, knowledge, and discovery tools in the conopeptide databaseBlockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculationsLess is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1.Boronic Acid Modifications Enhance the Anti-Influenza A Virus Activities of Novel Quindoline Derivatives.Synthesis and Cytotoxicity against K562 Cells of 3-O-Angeloyl-20-O-acetyl Ingenol, a Derivative of Ingenol MebutateIsothiouronium modification empowers pyrimidine-substituted curcumin analogs potent cytotoxicity and Golgi localization.De novo design of VEGFR-2 tyrosine kinase inhibitors based on a linked-fragment approach.Agonist and antagonist binding in human glycine receptors.α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition.Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins.Synthesis and DNA-binding properties of novel DNA cyclo-intercalators containing purine-glucuronic acid hybrids.Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products.The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site.2-Pyridinyl-4(3H)-quinazolinone: a scaffold for anti-influenza A virus compounds.Exploring the Relationship between Nicotinic Acetylcholine Receptor Ligand Size, Efficiency, Efficacy, and C-Loop Opening.Application of reverse docking for target prediction of marine compounds with anti-tumor activity.Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain.Development of efficient docking strategies and structure-activity relationship study of the c-Met type II inhibitors.Design and synthesis of neolamellarin a derivatives targeting heat shock protein 90.Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.Cytotoxic and glycosaminoglycan priming activities of novel 4-anilinequinazoline β-D-xylosides.Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-Gated Sodium Channels from Binding Energy Calculations.The unbinding studies of vascular endothelial growth factor receptor-2 protein tyrosine kinase type II inhibitors.A Novel Natural Influenza A H1N1 Virus Neuraminidase Inhibitory Peptide Derived from Cod Skin Hydrolysates and Its Antiviral MechanismNovel Natural Angiotensin Converting Enzyme (ACE)-Inhibitory Peptides Derived from Sea Cucumber-Modified Hydrolysates by Adding Exogenous Proline and a Study of Their Structure⁻Activity RelationshipMolecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor SubtypeDetermination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine ReceptorVirtual Screening Guided Design, Synthesis and Bioactivity Study of Benzisoselenazolones (BISAs) on Inhibition of c-Met and Its Downstream Signalling Pathways.Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations.Delineation of the unbinding pathway of α-conotoxin ImI from the α7 nicotinic acetylcholine receptorPartial activation of α7 nicotinic acetylcholine receptors: insights from molecular dynamics simulationsRole of an Absolutely Conserved Tryptophan Pair in the Extracellular Domain of Cys-Loop ReceptorsInvestigation of α-conotoxin unbinding using umbrella samplingExploring the binding energy profiles of full agonists, partial agonists, and antagonists of the α7 nicotinic acetylcholine receptorEfficient Synthesis of Five Types of Heterocyclic Compounds via Intramolecular Elimination Using Ultrasound-Static Heating TechniqueInfluences of disulfide connectivity on structure and antimicrobial activity of tachyplesin IEnhanced Activity against Multidrug-Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling PathwayDimerization of α-Conotoxins as a Strategy to Enhance the Inhibition of the Human α7 and α9α10 Nicotinic Acetylcholine ReceptorsStructure-activity relationship of propylene glycol alginate sodium sulfate derivatives for blockade of selectins binding to tumor cellsCentipede Venom Peptides Acting on Ion Channels
P50
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P50
description
researcher ORCID ID = 0000-0001-6625-2014
@en
wetenschapper
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name
Rilei Yu
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Rilei Yu
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Rilei Yu
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Rilei Yu
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type
label
Rilei Yu
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Rilei Yu
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Rilei Yu
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Rilei Yu
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prefLabel
Rilei Yu
@ast
Rilei Yu
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Rilei Yu
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Rilei Yu
@nl
P1153
37262222700
P31
P496
0000-0001-6625-2014