about
In vitro culture medium influences the vaccine efficacy of Mycobacterium bovis BCGLangerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cellsAnthrax lethal toxin-mediated killing of human and murine dendritic cells impairs the adaptive immune responseSynthetic glycolipid activators of natural killer T cells as immunotherapeutic agentsMechanisms for Glycolipid Antigen-Driven Cytokine Polarization by V 14i NKT CellsA Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T CellsA semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition propertiesRecognition of β-linked self glycolipids mediated by natural killer T cell antigen receptorsHuman and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen ComplexV 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigenStructural Basis for the Recognition of C20:2-αGalCer by the Invariant Natural Killer T Cell Receptor-like Antibody L363Glycolipids that Elicit IFN-γ-Biased Responses from Natural Killer T CellsCurrent efforts and future prospects in the development of live mycobacteria as vaccinesHuman NKT cells express granulysin and exhibit antimycobacterial activityMultiple immuno-regulatory defects in type-1 diabetesMycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cellsMycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 productionLysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosisMycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in miceMycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector moleculeDeletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent miceImproving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cellsMycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis.Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity.Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries.A critical role for CD8 T cells in a nonhuman primate model of tuberculosis.Recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8+ T cell responses against human immunodeficiency virus type 1 Env and M. tuberculosis in neonatal mice.Lipid and glycolipid antigens of CD1d-restricted natural killer T cells.A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivityΑ-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agentsA rapid fluorescence-based assay for classification of iNKT cell activating glycolipids.Bird genes give new insights into the origins of lipid antigen presentation.Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides.Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis.Distinct and overlapping effector functions of expanded human CD4+, CD8α+ and CD4-CD8α- invariant natural killer T cellsDevelopment of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia.Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosisSimilarities and differences between selective and nonselective BAFF blockade in murine SLEThe bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Steven A Porcelli
@ast
Steven A Porcelli
@en
Steven A Porcelli
@es
Steven A Porcelli
@nl
type
label
Steven A Porcelli
@ast
Steven A Porcelli
@en
Steven A Porcelli
@es
Steven A Porcelli
@nl
prefLabel
Steven A Porcelli
@ast
Steven A Porcelli
@en
Steven A Porcelli
@es
Steven A Porcelli
@nl
P106
P21
P31
P496
0000-0002-4441-9888