about
Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase IDefinition and redesign of the extended substrate specificity of granzyme B.Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs).Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors.NK cells in gamma-interferon-deficient mice suppress lung innate immunity against Mycoplasma sppRNKP-1, a novel natural killer-associated serine protease gene cloned from RNK-16 cytotoxic lymphocytes.Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules.Binding of granzyme B in the nucleus of target cells. Recognition of an 80-kilodalton protein.Properties of human blood monocytes. I. CD91 expression and log orthogonal light scatter provide a robust method to identify monocytes that is more accurate than CD14 expression.Properties of human blood monocytes. II. Monocytes from healthy adults are highly heterogeneous within and among individuals.Interactions between human natural killer (NK) lymphocytes and yeast cells: human NK cells do not kill Candida albicans, although C. albicans blocks NK lysis of K562 cells.Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity.Hydrolysis of tumor cell lipids after CTL-mediated death.Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C).Synthesis and kinetic studies of diphenyl 1-(N-peptidylamino)alkanephosphonate esters and their biotinylated derivatives as inhibitors of serine proteases and probes for lymphocyte granzymes.Proteases and lymphocyte cytotoxic killing mechanisms.Lysis by RNK-16 cytotoxic lymphocyte granules. Rate assays and conditions to study control of cytolysis.Fluorescent derivatives of diphenyl [1-(N-peptidylamino)alkyl]phosphonate esters: synthesis and use in the inhibition and cellular localization of serine proteases.Conversion of the substrate specificity of mouse proteinase granzyme B.Low dose IL-15 induces snap arming of CD44(low) T lymphocytes in the absence of antigen.Regulation of perforin lysis: implications for protein disulfide isomerase proteins.Localization, implications for function, and gene expression of chymotrypsin-like proteinases of cytotoxic RNK-16 lymphocytes.Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens: multiclonal responses that are extremely lytic if triggered and short-lived after cytokine withdrawal.Selective isocoumarin serine protease inhibitors block RNK-16 lymphocyte granule-mediated cytolysis.Dipeptidyl peptidase I: importance of progranzyme activation sequences, other dipeptide sequences, and the N-terminal amino group of synthetic substrates for enzyme activity.Sulfonyl fluoride serine protease inhibitors inactivate RNK-16 lymphocyte granule proteases and reduce lysis by granule extracts and perforin.IL-15-mediated induction of LFA-1 is a late step required for cytotoxic differentiation of human NK cells from CD34+Lin- bone marrow cells.An improved method to quantify human NK cell-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) per IgG FcR-positive NK cell without purification of NK cells.Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease.Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition.Perforin-enhancing protein, a low molecular weight protein of cytotoxic lymphocyte granules, enhances perforin lysis.Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase.cDNA cloning of granzyme J.Assessment of a role for phospholipase A2 and arachidonic acid metabolism in human lymphocyte natural cytotoxicity.Calreticulin, a component of the endoplasmic reticulum and of cytotoxic lymphocyte granules, regulates perforin-mediated lysis in the hemolytic model system.The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitorsSynthetic substrates and inhibitors for serine proteases from lymphocytes, mast cells, semen, and bloodLymphocyte granule-mediated cytolysis requires serine protease activityA serine proteinase as a "trigger" for human natural killer lymphocyte-mediated cytolysisCell surface thiols, methylation, and complement-like components are involved in the early events of CML whereas proteases participate in the later, Ca++-dependent events
P50
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P50
description
academisch docent
@nl
cell biologist
@en
name
Dorothy Hudig
@ast
Dorothy Hudig
@en
Dorothy Hudig
@es
Dorothy Hudig
@nl
type
label
Dorothy Hudig
@ast
Dorothy Hudig
@en
Dorothy Hudig
@es
Dorothy Hudig
@nl
prefLabel
Dorothy Hudig
@ast
Dorothy Hudig
@en
Dorothy Hudig
@es
Dorothy Hudig
@nl
P21
P31
P496
0000-0001-5952-208X