about
The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structureSorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulationA role for SNX5 in the regulation of macropinocytosisC9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal traffickingThe trans-Golgi network GRIP-domain proteins form alpha-helical homodimersClathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regenerationEmerging Insights into the Roles of Membrane Tethers from Analysis of Whole Organisms: The Tip of an Iceberg?The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradationp230 is associated with vesicles budding from the trans-Golgi networkSteady-state localization of a medial-Golgi glycosyltransferase involves transit through the trans-Golgi networkAntigenic determinants of a plant proteoglycan, the Gladiolus style arabinogalactan-proteinGRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network.Membrane tetheringMammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN.A novel mammalian retromer component, Vps26B.CD4+ CD25+ regulatory T cells modulate the T-cell and antibody responses in helicobacter-infected BALB/c mice.Rab9-dependent retrograde transport and endosomal sorting of the endopeptidase furin.Intracellular sorting and transport of proteins.Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis.The Golgi apparatus in the endomembrane-rich gastric parietal cells exist as functional stable mini-stacks dispersed throughout the cytoplasmIdentification of an endocytosis motif in an intracellular loop of Wntless protein, essential for its recycling and the control of Wnt protein signalingDomains of the TGN: coats, tethers and G proteins.The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network.Shaping the T cell repertoire to a bona fide autoantigen: lessons from autoimmune gastritis.SNX5 is essential for efficient macropinocytosis and antigen processing in primary macrophages.A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivoNew insights into membrane trafficking and protein sorting.Leishmania adaptor protein-1 subunits are required for normal lysosome traffic, flagellum biogenesis, lipid homeostasis, and adaptation to temperatures encountered in the mammalian host.Impact of glycans on T-cell tolerance to glycosylated self-antigens.Imaging and Quantitation Techniques for Tracking Cargo along Endosome-to-Golgi Transport Pathways.TGN golgins, Rabs and cytoskeleton: regulating the Golgi trafficking highways.Shaping the T-cell repertoire in the periphery.Endosome-to-Golgi transport pathways in physiological processes.The regulation of endosome-to-Golgi retrograde transport by tethers and scaffolds.Intracellular trafficking of the β-secretase and processing of amyloid precursor protein.Cargo trafficking between endosomes and the trans-Golgi network.The role of endosomes in innate and adaptive immunity.Dysregulation of intracellular trafficking and endosomal sorting in Alzheimer's disease: controversies and unanswered questions.Application of flow cytometry to analyze intracellular location and trafficking of cargo in cell populations.High-throughput quantitation of intracellular trafficking and organelle disruption by flow cytometry.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Paul A Gleeson
@ast
Paul A Gleeson
@en
Paul A Gleeson
@es
Paul A Gleeson
@nl
type
label
Paul A Gleeson
@ast
Paul A Gleeson
@en
Paul A Gleeson
@es
Paul A Gleeson
@nl
prefLabel
Paul A Gleeson
@ast
Paul A Gleeson
@en
Paul A Gleeson
@es
Paul A Gleeson
@nl
P106
P31
P496
0000-0002-5336-6503