P185
The challenge of atropisomerism in drug discoveryContra-Friedel–Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylationFoldamer-Mediated Remote Stereocontrol: >1,60 Asymmetric InductionN,N'-diarylureas: a new family of atropisomers exhibiting highly diastereoselective reactivity.Reproducibility of tract segmentation between sessions using an unsupervised modelling-based approach.Length-Dependent Formation of Transmembrane Pores by 310-Helical α-Aminoisobutyric Acid Foldamers.Stereochemical relays: communication via conformation.Transmission of stereochemical information over nanometre distances in chemical reactions.Quaternary centres bearing nitrogen (α-tertiary amines) as products of molecular rearrangements.Asymmetric synthesis of tertiary thiols and thioethers.Refoldable Foldamers: Global Conformational Switching by Deletion or Insertion of a Single Hydrogen Bond.Synthesis of enantiomerically enriched (R)-C-labelled 2-aminoisobutyric acid (Aib) by conformational memory in the alkylation of a derivative of L-alanine.Carbamate-directed benzylic lithiation for the diastereo- and enantioselective synthesis of diaryl ether atropisomers.Dynamic foldamer chemistry.Carbolithiation of N-alkenyl ureas and N-alkenyl carbamates.Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotinyl-substituted esters and ketones.Enzymatic desymmetrising redox reactions for the asymmetric synthesis of biaryl atropisomers.Conformational Switching of a Foldamer in a Multicomponent System by pH-Filtered Selection between Competing Noncovalent Interactions.On the control of secondary carbanion structure utilising ligand effects during directed metallation.Asymmetric synthesis of biaryl atropisomers by dynamic resolution on condensation of biaryl aldehydes with (-)-ephedrine or a proline-derived diamine.A tendril perversion in a helical oligomer: trapping and characterizing a mobile screw-sense reversalLooking forward to volume six.Sequential double α-arylation of N-allylureas by asymmetric deprotonation and N→C aryl migration.The origin of the conformational preference of N,N'-diaryl-N,N'-dimethyl ureas.Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases.Organometallic reagents: deconstructing THF.Tandem beta-alkylation-alpha-arylation of amines by carbolithiation and rearrangement of N-carbamoyl enamines (vinyl ureas).Synthesis of (-)-(S,S)-clemastine by invertive N --> C aryl migration in a lithiated carbamate.N-versus C-terminal control over the screw-sense preference of the configurationally achiral, conformationally helical peptide motif Aib(8)GlyAib(8).Beilstein Journal of Organic Chemistry.Direct synthesis of sulfonated azacalixarenes in water.Stereodynamics of bond rotation in tertiary aromatic amides.Lithium-sulfoxide-lithium exchange for the asymmetric synthesis of atropisomers under thermodynamic control.Asymmetric deprotonation and dearomatising cyclisation of N-benzyl benzamides using chiral lithium amides: formal synthesis of (-)-kainic acid.Carbolithiation of aromatic rings: cyclohexadienes from N-aroyl-2,2,6,6-tetramethylpiperidines.Stereospecific photochemical ring expansion of lithiated benzamides.Beta-lactams or gamma-lactams by 4-exo-trig or 5-endo-trig anionic cyclisation of lithiated acrylamide derivatives.Left-handed helical preference in an achiral peptide chain is induced by an L-amino acid in an N-terminal type II β-turn.Dearomatising rearrangements of lithiated thiophenecarboxamides.Thionoglycine as a multifunctional spectroscopic reporter of screw-sense preference in helical foldamers.
P50
Q28253152-AD94C44B-2641-41EA-AFC8-027E90FCFB55Q29041507-A91B4E42-7955-4C7C-A618-BA66B1B0ACBAQ30052043-51E76879-FD0C-480E-9BCE-C17A3EC7D48AQ31152049-83FE7BF6-BED6-42FC-9B74-7B0D77490796Q33400166-4B4D7AA4-6A52-4AC4-9624-508C5875D988Q33400166-781B0391-3445-4BD1-AC9A-4882D567EC14Q35877407-57A0C007-2481-40FF-A058-978A18F23B09Q36529806-E935A6A1-20AB-4C9E-B3F7-6CED95FB8F37Q37423899-33C4EE13-CDEF-419E-BF98-3D2B8DBAE7F9Q37850332-7AD8945C-7A3A-4995-8D28-76FBFCB833BFQ37885738-DB2B2CA6-4774-46D4-94F7-005819A3BFA2Q38496042-FD00709A-A3F5-4A2E-AE9B-03696BD5D66CQ38818746-8C4FE0A8-0162-450E-A0FA-B1B97B8AB073Q38818795-9DDDD9FC-1D62-4DCF-8EAD-6900F1F3E5A9Q38898016-0281F146-0EEE-4ADC-972C-7F0B3630B8B4Q39907462-F1648AF3-C488-424A-8D08-F333974A7792Q40683327-3F2280F1-1F48-4709-A591-33C4EEA8C35DQ41178900-6B8131EF-C071-4A23-B4E9-7B3D7E95C773Q41922636-0416EF1D-6A35-41C5-BC3D-4DA05CBD2524Q41954476-2525B479-9624-40D4-852D-0BB36A676248Q41962109-DBFE819C-A718-46AC-B18D-84EBF40F3907Q42292799-A785BC1C-9A5B-43A1-8354-ADB648AAC0D8Q42779569-038E75CB-DFC6-4F4A-9C43-DBF5D1F7E20AQ42827078-9456C84F-9922-481D-B3DC-46097F38B2C5Q42856319-9B4DA435-C482-487A-BA1F-FEA64AF5A614Q42935403-64CFD4E6-361B-43BC-A345-DEC2FCDE7F07Q43008348-28763644-7DAC-4185-98DB-93E4D7C8C8ABQ43089129-ADAB4B8C-723B-4957-BA51-0CE677A57C51Q43092303-E7CB1FC6-CF47-4404-A594-F2BFA352DC28Q43128069-FF2C4FAC-E5E2-4B5F-9CE2-F3DC5D8DDB9FQ43239120-31CC9560-E5F3-4EBA-BFDE-B8FF62C769EDQ43243914-2E3563B4-D779-49E7-AB7F-2B3B95C7F0B3Q43938611-49F34204-52E2-4E5D-B475-793220A21DB1Q43983699-3D559B1D-FEB0-4B98-9D2B-43C3D9BFED21Q44065573-CE50420D-7018-4E71-9B0A-95D789EE6E9AQ44162127-EA33B678-EA6B-4045-B949-F4A54ACD3EECQ44531741-0619BBBC-3211-4A23-A222-E72FECF73EE4Q44640036-0F880588-ADBA-4823-A253-1A8065C6D4B3Q44802381-4449EB77-3B05-4594-95EF-63C627183353Q45130397-68743E5C-6312-4947-93B6-9F143D16B352
P50
description
British chemist
@en
British chemist
@en-ca
British chemist
@en-gb
Brits scheikundige
@nl
Suurbritannia keemik
@et
britischer Chemiker
@de
chimist britanic
@ro
chimiste britannique
@fr
kimist britanik
@sq
químic britànic
@ca
name
Jonathan Clayden
@ast
Jonathan Clayden
@ca
Jonathan Clayden
@de
Jonathan Clayden
@en
Jonathan Clayden
@es
Jonathan Clayden
@fr
Jonathan Clayden
@it
Jonathan Clayden
@nl
Jonathan Clayden
@sl
Кляйден, Джонатан
@ru
type
label
Jonathan Clayden
@ast
Jonathan Clayden
@ca
Jonathan Clayden
@de
Jonathan Clayden
@en
Jonathan Clayden
@es
Jonathan Clayden
@fr
Jonathan Clayden
@it
Jonathan Clayden
@nl
Jonathan Clayden
@sl
Кляйден, Джонатан
@ru
prefLabel
Jonathan Clayden
@ast
Jonathan Clayden
@ca
Jonathan Clayden
@de
Jonathan Clayden
@en
Jonathan Clayden
@es
Jonathan Clayden
@fr
Jonathan Clayden
@it
Jonathan Clayden
@nl
Jonathan Clayden
@sl
Кляйден, Джонатан
@ru
P166
P1006
P214
P227
P244
P268
P269
P1006
P106
P184
P19
P21
P213
0000 0000 7144 4718
P214
P227
P244
no00084724