about
Heterocyclic analogs of xanthiones: 5,6-fused 3-methyl-1-phenylpyrano[2,3-c]pyrazol-4(1H) thiones-synthesis and NMR ((1)H, (13)C, (15)N) data.Heterocyclic analogues of xanthone and xanthione. 1H-pyrano[2,3-c:6,5-c]dipyrazol-4(7H)-ones and thiones: synthesis and NMR data.Development of potential selective and reversible pyrazoline based MAO-B inhibitors as MAO-B PET tracer precursors and reference substances for the early detection of Alzheimer's disease.Azido derivatives of cellobiose: oxidation at C1 with cellobiose dehydrogenase from Sclerotium rolfsii.Eulophia macrobulbon - an orchid with significant anti-inflammatory and antioxidant effect and anticancerogenic potential exerted by its root extract.Compounds from Caesalpinia sappan with anti-inflammatory properties in macrophages and chondrocytes.Use of activated enol ethers in the synthesis of pyrazoles: reactions with hydrazine and a study of pyrazole tautomerism.Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives.Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives.Structures of Highly Twisted Amides Relevant to Amide N-C Cross-Coupling: Evidence for Ground-State Amide Destabilization.Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II.Synthesis and evaluation of indole, pyrazole, chromone and pyrimidine based conjugates for tumor growth inhibitory activities--development of highly efficacious cytotoxic agents.Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives.2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents.Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrrolo oximes.Chemoselective efficient synthesis of functionalized β-oxonitriles through cyanomethylation of Weinreb amides.Dipyrazolo[1,5-a:4',3'-c]pyridines - a new heterocyclic system accessed via multicomponent reaction.Synthesis of tetrasubstituted pyrazoles containing pyridinyl substituents.Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines - sequential versus multicomponent reaction approach.Heterocyclic analogs of thioflavones: synthesis and NMR spectroscopic investigations.Synthesis of α,β-unsaturated α'-haloketones through the chemoselective addition of halomethyllithiums to Weinreb amides.Addition of lithium carbenoids to isocyanates: a direct access to synthetically useful N-substituted 2-haloacetamides.Spiro-fused (C2)-azirino-(C4)-pyrazolones, a new heterocyclic system. Synthesis, spectroscopic studies and X-ray structure analysis.Highly efficient and chemoselective α-iodination of acrylate esters through Morita-Baylis-Hillman-type chemistry.Chemoselective CaO-mediated acylation of alcohols and amines in 2-methyltetrahydrofuran.Derivatives of pyrazinecarboxylic acid: 1H, 13C and 15N NMR spectroscopic investigations.Exploiting a "Beast" in Carbenoid Chemistry: Development of a Straightforward Direct Nucleophilic Fluoromethylation Strategy.Evidence and isolation of tetrahedral intermediates formed upon the addition of lithium carbenoids to Weinreb amides and N-acylpyrroles.Highly efficient synthesis of functionalized α-oxyketones via Weinreb amides homologation with α-oxygenated organolithiums.First synthesis of 3-acetyl-2-aminothiophenes using the Gewald reaction.On the Tautomerism of N-Substituted Pyrazolones: 1,2-Dihydro-3H-pyrazol-3-ones versus 1H-Pyrazol-3-ols.Efficient Access to All-Carbon Quaternary and Tertiary α-Functionalized Homoallyl-type Aldehydes from Ketones.A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles.Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity.Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine transporter.Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.A convenient approach to heterocyclic building blocks: synthesis of novel ring systems containing a [5,6]Pyrano[2,3-c]pyrazol-4(1H)-one moiety.An unusual thionyl chloride-promoted C−C bond formation to obtain 4,4'-bipyrazolones.Design, synthesis and pharmacological evaluation of novel β2/3 subunit-selective γ-Aminobutyric Acid Type A (GABAA) receptor modulators
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Wolfgang Holzer
@ast
Wolfgang Holzer
@en
Wolfgang Holzer
@es
Wolfgang Holzer
@nl
type
label
Wolfgang Holzer
@ast
Wolfgang Holzer
@en
Wolfgang Holzer
@es
Wolfgang Holzer
@nl
prefLabel
Wolfgang Holzer
@ast
Wolfgang Holzer
@en
Wolfgang Holzer
@es
Wolfgang Holzer
@nl
P106
P1153
7006371933
P31
P496
0000-0001-8571-0535