about
SMIM1 underlies the Vel blood group and influences red blood cell traitsSeventy-five genetic loci influencing the human red blood cellSTAT5-mediated self-renewal of normal hematopoietic and leukemic stem cells.The TAK1-NF-κB axis as therapeutic target for AML.Cited2 is an essential regulator of adult hematopoietic stem cellsEx vivo assays to study self-renewal and long-term expansion of genetically modified primary human acute myeloid leukemia stem cells.Establishing long-term cultures with self-renewing acute myeloid leukemia stem/progenitor cells.Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation.Ex vivo assays to study self-renewal, long-term expansion, and leukemic transformation of genetically modified human hematopoietic and patient-derived leukemic stem cells.Constitutive cytoplasmic localization of p21(Waf1/Cip1) affects the apoptotic process in monocytic leukaemia.Mucin1 expression is enriched in the human stem cell fraction of cord blood and is upregulated in majority of the AML cases.CITED2 affects leukemic cell survival by interfering with p53 activation.Early detection and evolution of pre-leukemic clones in therapy-related myeloid neoplasms following autologous SCT.STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells.CITED2-mediated human hematopoietic stem cell maintenance is critical for acute myeloid leukemia.STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBPalpha.Constitutive activation of NF-kappa B is not sufficient to disturb normal steady-state hematopoiesisReintroduction of C/EBPalpha in leukemic CD34+ stem/progenitor cells impairs self-renewal and partially restores myelopoiesisCBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical InteractionsTranscriptional regulators CITED2 and PU.1 cooperate in maintaining hematopoietic stem cells
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Hein Schepers
@ast
Hein Schepers
@en
Hein Schepers
@es
Hein Schepers
@nl
type
label
Hein Schepers
@ast
Hein Schepers
@en
Hein Schepers
@es
Hein Schepers
@nl
prefLabel
Hein Schepers
@ast
Hein Schepers
@en
Hein Schepers
@es
Hein Schepers
@nl
P106
P31
P496
0000-0002-7731-3318