about
Characterisation of protein stability in rod-insert vaginal rings.Intravaginal immunization using the recombinant HIV-1 clade-C trimeric envelope glycoprotein CN54gp140 formulated within lyophilized solid dosage formsNon-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc.Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaquesVaginal rings for delivery of HIV microbicides.Vaginal microbicides for the prevention of HIV transmission.Sustained release of the candidate antiretroviral peptides T-1249 and JNJ54310516-AFP from a rod insert vaginal ringSustained release of proteins from a modified vaginal ring device.Microneedle mediated intradermal delivery of adjuvanted recombinant HIV-1 CN54gp140 effectively primes mucosal boost inoculations.Microbicide delivery: formulation technologies and strategies.Intravaginal immunisation using a novel antigen-releasing ring device elicits robust vaccine antigen-specific systemic and mucosal humoral immune responses.Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides.Vaginal gel drug delivery systems: understanding rheological characteristics and performance.Beyond HIV microbicides: multipurpose prevention technology products.Pharmacokinetics of the protein microbicide 5P12-RANTES in sheep following single dose vaginal gel administration.Microbicide vaginal rings: Technological challenges and clinical development.Packing Polymorphism of Dapivirine and Its Impact on the Performance of a Dapivirine-Releasing Silicone Elastomer Vaginal Ring.Matrix and reservoir-type multipurpose vaginal rings for controlled release of dapivirine and levonorgestrel.Molecular investigations into vaginal immunization with HIV gp41 antigenic construct H4A in a quick release solid dosage form.Characterization of the rheological, mucoadhesive, and drug release properties of highly structured gel platforms for intravaginal drug delivery.Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir.A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings.Influence of silicone elastomer solubility and diffusivity on the in vitro release of drugs from intravaginal rings.In vitro release of nonoxynol-9 from silicone matrix intravaginal rings.Design of a silicone reservoir intravaginal ring for the delivery of oxybutynin.Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings.A modified SILCS contraceptive diaphragm for long-term controlled release of the HIV microbicide dapivirine.Characterization of silicone elastomer vaginal rings containing HIV microbicide TMC120 by Raman spectroscopy.Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings.Controlling levonorgestrel binding and release in a multi-purpose prevention technology vaginal ring device.Intravaginal rings for continuous low-dose administration of cervical ripening agentsImpact of ring size and drug loading on the pharmacokinetics of a combination dapivirine-darunavir vaginal ring in cynomolgus macaquesHigh speed DSC (hyper-DSC) as a tool to measure the solubility of a drug within a solid or semi-solid matrixVaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTESHigh-performance liquid chromatographic determination of 17beta-estradiol and 17beta-estradiol-3-acetate solubilities and diffusion coefficents in silicone elastromeric intravaginal ringsDevelopment of liposome gel based formulations for intravaginal delivery of the recombinant HIV-1 envelope protein CN54gp140Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV-negative womenLack of in vitro-in vivo correlation for a UC781-releasing vaginal ring in macaquesSolid state 13C NMR spectroscopy provides direct evidence for reaction between ethinyl estradiol and a silicone elastomer vaginal ring drug delivery systemIn vitro release testing methods for drug-releasing vaginal rings
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Karl Malcolm
@ast
Karl Malcolm
@en
Karl Malcolm
@es
Karl Malcolm
@nl
type
label
Karl Malcolm
@ast
Karl Malcolm
@en
Karl Malcolm
@es
Karl Malcolm
@nl
prefLabel
Karl Malcolm
@ast
Karl Malcolm
@en
Karl Malcolm
@es
Karl Malcolm
@nl
P106
P1153
56441088300
7101933622
P31
P496
0000-0002-1276-7095