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Roles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity.Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes.Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats.Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets.
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description
researcher
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wetenschapper
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հետազոտող
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name
Lara Bellini
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Lara Bellini
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Lara Bellini
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Lara Bellini
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type
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Lara Bellini
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Lara Bellini
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Lara Bellini
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Lara Bellini
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Lara Bellini
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Lara Bellini
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Lara Bellini
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Lara Bellini
@nl
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0000-0003-1433-846X