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The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatmentEffects of growth/differentiation factor 5 on the survival and morphology of embryonic rat midbrain dopaminergic neurones in vitro6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo.TGF-beta and the regulation of neuron survival and death.Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson's disease.Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms.Progress in Parkinson's disease-where do we stand?Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease.The Epigenome as a therapeutic target for Parkinson's disease.Parkinson's disease in the nuclear age of neuroinflammation.Midbrain dopaminergic neurons: a review of the molecular circuitry that regulates their development.BMP-Smad 1/5/8 signalling in the development of the nervous system.Roles for the TGFβ superfamily in the development and survival of midbrain dopaminergic neurons.Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease.Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation.Viral vector delivery of neurotrophic factors for Parkinson's disease therapy.Zeb2: A multifunctional regulator of nervous system development.Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth.Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: A systematic review and meta-analysis.A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease.Neurotrophic factor therapy for Parkinson's disease: past, present and future.BMP2 and GDF5 induce neuronal differentiation through a Smad dependant pathway in a model of human midbrain dopaminergic neurons.Neurotrophic effects of growth/differentiation factor 5 in a neuronal cell line.Growth/differentiation factor 5 and glial cell line-derived neurotrophic factor enhance survival and function of dopaminergic grafts in a rat model of Parkinson's disease.Long-term protection of the rat nigrostriatal dopaminergic system by glial cell line-derived neurotrophic factor against 6-hydroxydopamine in vivo.Treatment with phosphotidylglycerol-based nanoparticles prevents motor deficits induced by proteasome inhibition: implications for Parkinson's disease.Interleukin-1β contributes to dopaminergic neuronal death induced by lipopolysaccharide-stimulated rat glia in vitro.Effects of GDF5 overexpression on embryonic rat dopaminergic neurones in vitro and in vivo.Viability of dopaminergic neurones is influenced by serum and astroglial cells in vitro.Neuroprotective effects of delayed administration of growth/differentiation factor-5 in the partial lesion model of Parkinson's disease.Expression of growth differentiation factor-5 in the developing and adult rat brain.Donor age affects differentiation of rat ventral mesencephalic stem cells.Ventral midbrain neural stem cells have delayed neurogenic potential in vitro.Romidepsin induces caspase-dependent cell death in human neuroblastoma cells.Differential effects of GDF5 on the medial and lateral rat ventral mesencephalon.Targeting transcriptional regulators to regenerate midbrain dopaminergic axons in Parkinson's disease.Neuroprotective effects of growth/differentiation factor 5 depend on the site of administration.Tumour necrosis factor-alpha impairs neuronal differentiation but not proliferation of hippocampal neural precursor cells: Role of Hes1.An Attitudinal Survey of Undergraduate Neuroscience Students Regarding Their Views on the Relevance of Lectures to their Education.Growth/differentiation factor 5 protects nigrostriatal dopaminergic neurones in a rat model of Parkinson's disease.
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Forscher
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Aideen M Sullivan
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Aideen M Sullivan
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Aideen M Sullivan
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Aideen M Sullivan
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Aideen M Sullivan
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Aideen M Sullivan
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