about
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexesGlutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.Both normal and polyglutamine- expanded ataxin-7 are components of TFTC-type GCN5 histone acetyltransferase- containing complexesTra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complexThe Hos2 Histone Deacetylase Controls Ustilago maydis Virulence through Direct Regulation of Mating-Type GenesTranscriptional alterations and chromatin remodeling in polyglutamine diseases.The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.Histone deacetylases: revealing the molecular base of dimorphism in pathogenic fungi.Hsp70 and Hsp40 chaperones do not modulate retinal phenotype in SCA7 mice.Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter.Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model.Long-term engraftment of systemically transplanted, gene-modified bone marrow-derived cells in the adult mouse retina.Sharing the SAGA.TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.New insights into the SAGA complex from studies of the Tra1 subunit in budding and fission yeast.SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell typesRôle d’une désorganisation de la chromatine dans la neurodégénérescence due à une expansion de polyglutamine dans l’ataxine-7Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeastNew insights into the evolutionary conservation of the sole PIKK pseudokinase Tra1/TRRAP[The TOR SAGA to the rescue of starved yeast cells]
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description
investigador
@es
researcher
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wetenschapper
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name
Dom Helmlinger
@ast
Dom Helmlinger
@en
Dom Helmlinger
@nl
type
label
Dom Helmlinger
@ast
Dom Helmlinger
@en
Dom Helmlinger
@nl
prefLabel
Dom Helmlinger
@ast
Dom Helmlinger
@en
Dom Helmlinger
@nl
P106
P31
P496
0000-0003-1501-0423