about
Evidence and controversies on the role of XMRV in prostate cancer and chronic fatigue syndromeRibonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system.Targeting HIV: antiretroviral therapy and development of drug resistance.Fitness variations and their impact on the evolution of antiretroviral drug resistance.HIV-resistance to viral entry inhibitors.Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.HIV-1 Adapts To Replicate in Cells Expressing Common Marmoset APOBEC3G and BST2Insertions and deletions in HIV-1 reverse transcriptase: consequences for drug resistance and viral fitness.Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase.HIV-1 protease dimer interface mutations that compensate for viral reverse transcriptase instability in infectious virions.Effect of the human immunodeficiency virus type 1 reverse transcriptase polymorphism Leu-214 on replication capacity and drug susceptibility.Characterization of two distinct early post-entry blocks to HIV-1 in common marmoset lymphocytes.Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.Molecular basis of human immunodeficiency virus drug resistance: an update.HIV-1 reverse transcriptase connection subdomain mutations involved in resistance to approved non-nucleoside inhibitors.Mutation rates and intrinsic fidelity of retroviral reverse transcriptases.Molecular basis of human immunodeficiency virus type 1 drug resistance: overview and recent developments.Antiretroviral therapy and drug resistance in human immunodeficiency virus type 2 infection.Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance.Mechanistic insights into the role of Val75 of HIV-1 reverse transcriptase in misinsertion and mispair extension fidelity of DNA synthesis.Studies on the effects of truncating alpha-helix E' of p66 human immunodeficiency virus type 1 reverse transcriptase on template-primer binding and fidelity of DNA synthesis.Special issue: retroviral enzymes.Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients.Viral reverse transcriptases.Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments.SAMHD1 is active in cycling cells permissive to HIV-1 infection.Tryptophan scanning mutagenesis of aromatic residues within the polymerase domain of HIV-1 reverse transcriptase: critical role of Phe-130 for p51 function and second-site revertant restoring viral replication capacity.Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis.Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis.Amino acid substitutions away from the RNase H catalytic site increase the thermal stability of Moloney murine leukemia virus reverse transcriptase through RNase H inactivation.Major groove binding track residues of the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase enhance cDNA synthesis at high temperatures.Temperature effects on the fidelity of a thermostable HIV-1 reverse transcriptase.Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapyHIV protease cleaves poly(A)-binding protein.Thymidine analogue excision and discrimination modulated by mutational complexes including single amino acid deletions of Asp-67 or Thr-69 in HIV-1 reverse transcriptase.Engineering protein thermal stability. Sequence statistics point to residue substitutions in alpha-helices.Investigation of the dNTP-binding site of HIV-1 reverse transcriptase using photoreactive analogs of dNTP.Characterization of the reverse transcriptase of a human immunodeficiency virus type 1 group O isolate.Multidrug-resistant HIV-1 reverse transcriptase: involvement of ribonucleotide-dependent phosphorolysis in cross-resistance to nucleoside analogue inhibitors.
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description
investigador
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researcher
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wetenschapper
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name
Luis Menendez Arias
@ast
Luis Menendez Arias
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Luis Menendez Arias
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Luis Menendez Arias
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Luis Menendez Arias
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type
label
Luis Menendez Arias
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Luis Menendez Arias
@de
Luis Menendez Arias
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Luis Menendez Arias
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Luis Menendez Arias
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prefLabel
Luis Menendez Arias
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Luis Menendez Arias
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Luis Menendez Arias
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Luis Menendez Arias
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Luis Menendez Arias
@nl
P1053
N-7447-2016
P106
P1153
7004203204
P31
P496
0000-0002-1251-6640