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The NMDA Receptor NR1 C1 Region Bound to Calmodulin: Structural Insights into Functional Differences between Homologous DomainsStructural and Energetic Determinants of Apo Calmodulin Binding to the IQ Motif of the NaV1.2 Voltage-Dependent Sodium ChannelPhenylalanine fluorescence studies of calcium binding to N-domain fragments of Paramecium calmodulin mutants show increased calcium affinity correlates with increased disorderAllosteric effects of the antipsychotic drug trifluoperazine on the energetics of calcium binding by calmodulinEnergetics of calmodulin domain interactions with the calmodulin binding domain of CaMKII.Calcium binding to calmodulin mutants monitored by domain-specific intrinsic phenylalanine and tyrosine fluorescence.Quantitative model for gene regulation by lambda phage repressorCalcium-dependent energetics of calmodulin domain interactions with regulatory regions of the Ryanodine Receptor Type 1 (RyR1)Recognition of β-calcineurin by the domains of calmodulin: thermodynamic and structural evidence for distinct rolesCalmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulinHEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells.Biochemical properties of V91G calmodulin: A calmodulin point mutation that deregulates muscle contraction in Drosophila.Regulation of calcium/calmodulin-dependent protein kinase II docking to N-methyl-D-aspartate receptors by calcium/calmodulin and alpha-actinin.Thermodynamic linkage between calmodulin domains binding calcium and contiguous sites in the C-terminal tail of Ca(V)1.2.Lobe-dependent regulation of ryanodine receptor type 1 by calmodulin.Apo-calmodulin binds with its C-terminal domain to the N-methyl-D-aspartate receptor NR1 C0 region.Interdomain cooperativity of calmodulin bound to melittin preferentially increases calcium affinity of sites I and II.The neuronal voltage-dependent sodium channel type II IQ motif lowers the calcium affinity of the C-domain of calmodulin.The Nkd EF-hand domain modulates divergent wnt signaling outputs in zebrafish.Backbone resonance assignments of complexes of human voltage-dependent sodium channel NaV1.2 IQ motif peptide bound to apo calmodulin and to the C-domain fragment of apo calmodulin.Backbone and side-chain resonance assignments of (Ca2+)4-calmodulin bound to beta calcineurin A CaMBD peptide.Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel NaV1.2.Calcium-induced interactions of calmodulin domains revealed by quantitative thrombin footprinting of Arg37 and Arg106.Subunit hybridization studies of partially ligated cyanomethemoglobins using a cryogenic method. Evidence for three allosteric states.Paramecium calmodulin mutants defective in ion channel regulation can bind calcium and undergo calcium-induced conformational switching.The OR control system of bacteriophage lambda. A physical-chemical model for gene regulationAnalysis of site-specific interaction parameters in protein-DNA complexesEnergetics of cooperative protein-DNA interactions: comparison between quantitative deoxyribonuclease footprint titration and filter bindingFree energy coupling within macromolecules. The chemical work of ligand binding at the individual sites in co-operative systemsDiscontinuous equilibrium titrations of cooperative calcium binding to calmodulin monitored by 1-D 1H-nuclear magnetic resonance spectroscopyBohr effects of the partially-ligated (CN-met) intermediates of hemoglobin as probed by quaternary assemblyQuantitative endoproteinase GluC footprinting of cooperative Ca2+ binding to calmodulin: proteolytic susceptibility of E31 and E87 indicates interdomain interactionsProteolytic footprinting titrations for estimating ligand-binding constants and detecting pathways of conformational switching of calmodulinAn interdomain linker increases the thermostability and decreases the calcium affinity of the calmodulin N-domainCalcium-induced conformational switching of Paramecium calmodulin provides evidence for domain couplingBasic interdomain boundary residues in calmodulin decrease calcium affinity of sites I and II by stabilizing helix-helix interactionsCalcium binding to calmodulin mutants having domain-specific effects on the regulation of ion channelsBackbone resonance assignments of complexes of apo human calmodulin bound to IQ motif peptides of voltage-dependent sodium channels NaV1.1, NaV1.4 and NaV1.7.
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