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Determination of cellularly processed HLA-A2402-restricted novel CTL epitopes derived from two cancer germ line genes, MAGE-A4 and SAGEEpirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell ActivityGuanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell TypesAdoptive transfer of genetically modified Wilms' tumor 1-specific T cells in a novel malignant skull base meningioma modelDecreased ADAMTS13 activity in plasma from patients with thrombotic thrombocytopenic purpura.Reduced Cd4+Cd25+ T cells in patients with idiopathic thrombocytopenic purpura.Dose-dependent effects of NY-ESO-1 protein vaccine complexed with cholesteryl pullulan (CHP-NY-ESO-1) on immune responses and survival benefits of esophageal cancer patients.Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation.Identification of an immunogenic neo-epitope encoded by mouse sarcoma using CXCR3 ligand mRNAs as sensors.Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induced tumor necrosis factor receptor.Intratumoral injection of Propionibacterium acnes suppresses malignant melanoma by enhancing Th1 immune responses.De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients.In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines.Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation.A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy.Definition of target antigens for naturally occurring CD4(+) CD25(+) regulatory T cellsDe novo CD5-positive diffuse large B-cell lymphoma of the temporal bone presenting with an external auditory canal tumor.Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor.CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicityTime-dependent transition of the immunoglobulin G subclass and immunoglobulin E response in cancer patients vaccinated with cholesteryl pullulan-melanoma antigen gene-A4 nanogel.Limited expression of cancer-testis antigens in renal cell carcinoma patients.Adoptive immunotherapy of cancer utilizing genetically engineered lymphocytes.Engineering hybrid exosomes by membrane fusion with liposomesAttempt to Harvest a Sufficient Number of Mononuclear Cells in an Appropriate Blood Product Volume By Modification of the Default Apheresis Setting.Development of Engineered T Cells Expressing a Chimeric CD16-CD3ζ Receptor to Improve the Clinical Efficacy of Mogamulizumab Therapy Against Adult T-Cell Leukemia.Nanogel-based immunologically stealth vaccine targets macrophages in the medulla of lymph node and induces potent antitumor immunity.Gene-modified human α/β-T cells expressing a chimeric CD16-CD3ζ receptor as adoptively transferable effector cells for anticancer monoclonal antibody therapy.Stimulation through very late antigen-4 and -5 improves the multifunctionality and memory formation of CD8⁺ T cells.Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury.Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: potential utility for adoptive immunotherapy.Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor-specific CD8+ T cells.Safety and persistence of WT1-specific T-cell receptor gene-transduced lymphocytes in patients with AML and MDS.Generation of peptide-specific CD8+ T cells by phytohemagglutinin-stimulated antigen-mRNA-transduced CD4+ T cells.In vitro stimulation of CD8 and CD4 T cells by dendritic cells loaded with a complex of cholesterol-bearing hydrophobized pullulan and NY-ESO-1 protein: Identification of a new HLA-DR15-binding CD4 T-cell epitope.IFN-gamma controls the generation/activation of CD4+ CD25+ regulatory T cells in antitumor immune response.Acute interstitial pneumonitis during chemotherapy for haematological malignancy.Clinical relevance of antigen spreading pattern induced by CHP-MAGE-A4 cancer vaccination.Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer.
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
Hiroshi Shiku
@en
Shiku H
@nl
type
label
Hiroshi Shiku
@en
Shiku H
@nl
altLabel
Shiku H
@en
prefLabel
Hiroshi Shiku
@en
Shiku H
@nl
P106
P31
P496
0000-0002-0362-755X