about
E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A)Characterisation of the antitrypanosomal activity of peptidyl alpha-aminoalkyl phosphonate diphenyl esters.The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'.Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function.Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.Measurement of matrix metalloproteinase activities in the medium of cultured synoviocytes using zymography.Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.Proteases involved in cartilage matrix degradation in osteoarthritis.Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilageCalcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases.Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 bExtracellular regulation of metalloproteinases.Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3.Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.Purification and characterisation of a trypsin-like serine oligopeptidase from Trypanosoma congolense.Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes.Invasive potential of human rheumatoid tenosynovial cells is in part MT1-MMP dependent.Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptorProduction of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMCProteases from Trypanosoma brucei brucei. Purification, characterisation and interactions with host regulatory moleculesADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cellsProduction of cytokines, vascular endothelial growth factor, matrix metalloproteinases, and tissue inhibitor of metalloproteinases 1 by tenosynovium demonstrates its potential for tendon destruction in rheumatoid arthritisThe role of matrix metalloproteinases in rheumatoid tendon diseaseZymography of metalloproteinasesMonitoring metalloproteinase activity using synthetic fluorogenic substratesAnalysis of TIMP expression and activityMonoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasmaHeparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic CartilageLRP1 Controls TNF Release via the TIMP-3/ADAM17 Axis in Endotoxin-Activated MacrophagesEffect of Polarization and Chronic Inflammation on Macrophage Expression of Heparan Sulfate Proteoglycans and Biosynthesis Enzymes
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
Linda Troeberg
@en
Linda Troeberg
@es
Linda Troeberg
@nl
type
label
Linda Troeberg
@en
Linda Troeberg
@es
Linda Troeberg
@nl
altLabel
L Troeberg
@en
prefLabel
Linda Troeberg
@en
Linda Troeberg
@es
Linda Troeberg
@nl
P106
P1960
DTANkVcAAAAJ
P21
P31
P496
0000-0003-0939-4651