about
Synthesis, characterisation, X-ray structure and biological activity of three new 5-formyluracil thiosemicarbazone complexes.Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells.Arsenic trioxide in hematological malignancies: the new discovery of an ancient drug.Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.Emerging Raf inhibitors.The p53 family protein p73 provides new insights into cancer chemosensitivity and targeting.Emerging MEK inhibitors.The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angioArsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells.Synthesis, spectroscopic characterization and biological properties of new natural aldehydes thiosemicarbazones.Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis.Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways.MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide-induced apoptosis.Human myeloma cells express the bone regulating gene Runx2/Cbfa1 and produce osteopontin that is involved in angiogenesis in multiple myeloma patientsProangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesisEarly Proinflammatory Activation of Renal Tubular Cells by Normal and Pathologic IgGSynthesis, structure, and spectroscopic properties of acetato(dimethyl)(pyridine-2-carbaldehydethiosemicarbazonato)tin(IV) acetic acid solvate, [SnMe2(PyTSC)(OAc)].HOAc. Comparison of its biological activity with that of some structurally related diAcenaphthenequinone thiosemicarbazone and its transition metal complexes: synthesis, structure, and biological activitySynthesis, structure, spectroscopic properties and biological activity of mixed diorganotin(IV) complexes containing pyridine-2-carbaldehyde thiosemicarbazonato and diphenyldithiophosphinato ligandsDownmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blastsMEK-ERK pathway is expressed but not activated in high proliferating, self-renewing cord blood hematopoietic progenitorsAir purification and indoor biologic pollutantsTransition-metal complexes of isatin-beta-thiosemicarbazone. X-ray crystal structure of two nickel complexesp73 and p53 pathway in human breast cancers
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description
researcher
@en
name
P Lunghi
@en
P Lunghi
@nl
type
label
P Lunghi
@en
P Lunghi
@nl
prefLabel
P Lunghi
@en
P Lunghi
@nl
P106
P31
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0000-0002-4416-7975