about
p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacityExperimental and in silico modelling analyses of the gene expression pathway for recombinant antibody and by-product production in NS0 cell linesExpression of Trypanosoma brucei gambiense Antigens in Leishmania tarentolae. Potential for Use in Rapid Serodiagnostic Tests (RDTs)NMR analysis of synthetic human serum albumin alpha-helix 28 identifies structural distortion upon amadori modification.Comparison of the effects of 2,2,2-trifluoroethanol on peptide and protein structure and function.The effect of peptide glycation on local secondary structure.The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control.Computational modelling elucidates the mechanism of ciliary regulation in health and disease.How can thermal processing modify the antigenicity of proteins?RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3.Biochemical and structural insights into bacterial organelle form and biogenesis.¹H NMR spectroscopy profiling of metabolic reprogramming of Chinese hamster ovary cells upon a temperature shift during culture.Rapid high-throughput characterisation, classification and selection of recombinant mammalian cell line phenotypes using intact cell MALDI-ToF mass spectrometry fingerprinting and PLS-DA modelling.Residual on column host cell protein analysis during lifetime studies of protein A chromatography.Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-ASThe cold-shock response in cultured mammalian cells: harnessing the response for the improvement of recombinant protein production.Control and regulation of the cellular responses to cold shock: the responses in yeast and mammalian systems.Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis.Quantitative definition and monitoring of the host cell protein proteome using iTRAQ - a study of an industrial mAb producing CHO-S cell line.Measurement and control of host cell proteins (HCPs) in CHO cell bioprocesses.Developments in the production of mucosal antibodies in plants.Polysome profiling of mAb producing CHO cell lines links translational control of cell proliferation and recombinant mRNA loading onto ribosomes with global and recombinant protein synthesis.Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein release in Chinese hamster ovary cells.Methionine sulfoximine supplementation enhances productivity in GS-CHOK1SV cell lines through glutathione biosynthesis.An ultra scale-down approach identifies host cell protein differences across a panel of mAb producing CHO cell line variants.Biotherapeutic protein formulation variables influence protein integrity and can promote post-translational modifications as shown using chicken egg white lysozyme as a model system.Alternative promoters regulate cold inducible RNA-binding (CIRP) gene expression and enhance transgene expression in mammalian cells.Host cell protein adsorption characteristics during protein A chromatography.Engineering the chaperone network of CHO cells for optimal recombinant protein production and authenticity.Metabolic rates, growth phase, and mRNA levels influence cell-specific antibody production levels from in vitro-cultured mammalian cells at sub-physiological temperatures.On the statistical analysis of the GS-NS0 cell proteome: imputation, clustering and variability testing.Comparative proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate.mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells.Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability.Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAsThe chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h.Investigating variables and mechanisms that influence protein integrity in low water content amorphous carbohydrate matrices.Protein modification during anti-viral heat-treatment bioprocessing of factor VIII concentrates, factor IX concentrates, and model proteins in the presence of sucrose.Lysozyme conjugate immune complex formation and the effects on substrate hydrolysis.The challenges of product- and process-related impurities to an evolving biopharmaceutical industry.
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
C M Smales
@en
C M Smales
@nl
type
label
C M Smales
@en
C M Smales
@nl
prefLabel
C M Smales
@en
C M Smales
@nl
P106
P31
P496
0000-0002-2762-4724