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Megalin in acute kidney injury: foe and friendFrom bowel to kidneys: the role of cubilin in physiology and diseaseMannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cellsThe endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis.Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney.Megalin dependent urinary cystatin C excretion in ischemic kidney injury in rats.Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2.Megalin-mediated specific uptake of chitosan/siRNA nanoparticles in mouse kidney proximal tubule epithelial cells enables AQP1 gene silencing.Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway.Role of megalin and cubilin in renal physiology and pathophysiology.The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology.Detailed investigations of proximal tubular function in Imerslund-Gräsbeck syndrome.Vitamin D in Tear Fluid.Endocytic receptors in the renal proximal tubule.Megalin antagonizes activation of the parathyroid hormone receptor.Megalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease.Megalin-deficiency causes high myopia, retinal pigment epithelium-macromelanosomes and abnormal development of the ciliary body in mice.Mutually dependent localization of megalin and Dab2 in the renal proximal tubule.Transcellular transport of vitamin B(12) in LLC-PK1 renal proximal tubule cells.Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule.Long-term enzyme replacement therapy is associated with reduced proteinuria and preserved proximal tubular function in women with Fabry disease.Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12).Abolishment of proximal tubule albumin endocytosis does not affect plasma albumin during nephrotic syndrome in mice.Diversity in rat tissue accumulation of vitamin B12 supports a distinct role for the kidney in vitamin B12 homeostasis.Mouse model of proximal tubule endocytic dysfunction.Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina DegenerationDistribution of alpha-galactosidase A in normal human kidney and renal accumulation and distribution of recombinant alpha-galactosidase A in Fabry miceRenal uptake of 99mTc-dimercaptosuccinic acid is dependent on normal proximal tubule receptor-mediated endocytosisEnzyme Replacement Therapy During Pregnancy in Fabry Patients : Review of Published Cases of Live Births and a New Case of a Severely Affected Female with Fabry Disease and Pre-eclampsia Complicating PregnancyImmature megalin expression in the preterm neonatal kidney is associated with urinary loss of vitamin carrier proteinsUrokinase-type plasminogen activator contributes to amiloride-sensitive sodium retention in nephrotic range glomerular proteinuria in miceThe authors replyThe Authors Reply
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
Nielsen R
@nl
Rikke Nielsen
@en
type
label
Nielsen R
@nl
Rikke Nielsen
@en
altLabel
Nielsen R
@en
prefLabel
Nielsen R
@nl
Rikke Nielsen
@en
P106
P31
P496
0000-0003-3105-3474