about
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytesIntersection of toxicogenomics and high throughput screening in the Tox21 program: an NIEHS perspectiveAn integrated stress response regulates amino acid metabolism and resistance to oxidative stressAssessing gene significance from cDNA microarray expression data via mixed modelsMicroarray data analysis of mouse neoplasia.Systematic variation normalization in microarray data to get gene expression comparison unbiased.CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data.Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes.Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages.Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.Use of transcriptomics in understanding mechanisms of drug-induced toxicityThe human decatenation checkpoint.Oxidative stress and cell cycle checkpoint function.Consistency of predictive signature genes and classifiers generated using different microarray platforms.Standardizing global gene expression analysis between laboratories and across platforms.An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damageDNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs.Genome-wide small RNA sequencing and gene expression analysis reveals a microRNA profile of cancer susceptibility in ATM-deficient human mammary epithelial cells.Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM.Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseasesGenomic indicators in the blood predict drug-induced liver injury.Blood gene expression signatures predict exposure levels.Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophenAtaxia telangiectasia-mutated dependent DNA damage checkpoint functions regulate gene expression in human fibroblasts.DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cellsGene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individualsMajor carcinogenic pathways identified by gene expression analysis of peritoneal mesotheliomas following chemical treatment in F344 rats.Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance.ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation.Molecular effects of 1-naphthyl-methylcarbamate and solar radiation exposures on human melanocytes.Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix.Correction: Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening.Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations.Computational selection of distinct class- and subclass-specific gene expression signatures.Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation.Gene expression profiling of rat livers reveals indicators of potential adverse effects.Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.Differential gene expression profiling in whole blood during acute systemic inflammation in lipopolysaccharide-treated rats.
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description
researcher
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wetenschapper
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name
Richard Paules
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Richard Paules
@nl
type
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Richard Paules
@en
Richard Paules
@nl
prefLabel
Richard Paules
@en
Richard Paules
@nl
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P2456
P31
P496
0000-0001-9106-7486