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An investigation on platelet transport during thrombus formation at micro-scale stenosisPI 3-kinase p110beta: a new target for antithrombotic therapyPhosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in miceImaging signaling processes in platelets.The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis.Dynamics of platelet thrombus formation.Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow.Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.Application of a strain rate gradient microfluidic device to von Willebrand's disease screening.Nonlinear Dynamic Modelling of Platelet Aggregation via Microfluidic Devices.Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood.The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells.Elastomeric microvalve geometry affects haemocompatibilityStructural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in miceA shear gradient–dependent platelet aggregation mechanism drives thrombus formationThe mode of anesthesia influences outcome in mouse models of arterial thrombosisSynergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin alpha IIbbeta 3. Studies in human platelets ans transfected Chinese hamster ovary cellsIdentification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formationA live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flowA multimode-TIRFM and microfluidic technique to examine platelet adhesion dynamicsIn vitro flow based systems to study platelet function and thrombus formation: Recommendations for standardization: Communication from the SSC on Biorheology of the ISTHActive Micropump-Mixer for Rapid Antiplatelet Drug Screening in Whole BloodThe PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition
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W S Nesbitt
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0000-0001-5644-7053