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The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast.Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesisMolecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis.Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesisHaploinsufficiency of COQ4 causes coenzyme Q10 deficiency.Is coenzyme Q a key factor in aging?Regulation of coenzyme Q biosynthesis in yeast: a new complex in the block.Mitochondrial responsibility in ageing process: innocent, suspect or guilty.Molecular diagnosis of coenzyme Q10 deficiency.The regulation of coenzyme q biosynthesis in eukaryotic cells: all that yeast can tell us.Generation, genome edition and characterization of iPSC lines from a patient with coenzyme Q10 deficiency harboring a heterozygous mutation in COQ4 gene.Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency.Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiaeGenetic evidence for coenzyme Q requirement in plasma membrane electron transport.Balanced CoQ6 biosynthesis is required for lifespan and mitophagy in yeast.Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity.Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p.The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q10 biosynthesis.Coenzyme Q6 and iron reduction are responsible for the extracellular ascorbate stabilization at the plasma membrane of Saccharomyces cerevisiaeCoenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis elegansDesign of High-Throughput Screening of Natural Extracts to Identify Molecules Bypassing Primary Coenzyme Q Deficiency in Saccharomyces cerevisiae
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
C Santos-Ocaña
@en
C Santos-Ocaña
@nl
type
label
C Santos-Ocaña
@en
C Santos-Ocaña
@nl
prefLabel
C Santos-Ocaña
@en
C Santos-Ocaña
@nl
P106
P31
P496
0000-0002-2379-796X