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Expedient synthesis of threo-beta-hydroxy-alpha-amino acid derivatives: phenylalanine, tyrosine, histidine, and tryptophanAn oxyanion-hole selective serine protease inhibitor in complex with trypsinBranched aliphatic alkanes with quaternary substituted carbon atoms in modern and ancient geologic samplesRadical chemistry associated with the thiocarbonyl groupSynthesis of the taxol AB-system by olefination of an A-ring C1 ketone and direct B-ring closureIs donor-acceptor hydrogen bonding necessary for 4,6-O-benzylidene-directed beta-mannopyranosylation? Stereoselective synthesis of beta-C-mannopyranosides and alpha-C-glucopyranosides.Heterobivalent library expansion by "living radical" processes: thiocarbonyl addition/elimination, and nitroxide-based reactions with fluorous deconvolution.S(N)2-type nucleophilic opening of beta-thiolactones (thietan-2-ones) as a source of thioacids for coupling reactions.Synthesis and structural verification of the xylomannan antifreeze substance from the freeze-tolerant Alaskan beetle Upis ceramboidesIdentification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.Bacillus anthracis o-succinylbenzoyl-CoA synthetase: reaction kinetics and a novel inhibitor mimicking its reaction intermediateAnomericity of T-2 toxin-glucoside: masked mycotoxin in cereal cropsThe 4-(tert-butyldiphenylsiloxy)-3-fluorobenzyl group: a new alcohol protecting group, fully orthogonal with the p-methoxybenzyl group and removable under desilylation conditions.Methodology development and physical organic chemistry: a powerful combination for the advancement of glycochemistry.Stereocontrolled synthesis of D- and L-beta-rhamnopyranosides with 4-O-6-S-alpha-cyanobenzylidene-protected 6-thiorhamnopyranosyl thioglycosides.Stereocontrolled synthesis of mannans and rhamnans.Influence of protecting groups on the reactivity and selectivity of glycosylation: chemistry of the 4,6-o-benzylidene protected mannopyranosyl donors and related species.Synthesis of the beta-rhamnopyranosides and the 6-deoxy-beta-mannoheptopyranosides.A propos of glycosyl cations and the mechanism of chemical glycosylation; the current state of the art.Direct Fmoc-chemistry-based solid-phase synthesis of peptidyl thioesters.Determination of the Influence of Side-Chain Conformation on Glycosylation Selectivity using Conformationally Restricted Donors.Probing the influence of protecting groups on the anomeric equilibrium in sialic acid glycosides with the persistent radical effectImportance of the 6'-hydroxy group and its configuration for apramycin activity.Revisiting the armed-disarmed concept: the importance of anomeric configuration in the activation of S-benzoxazolyl glycosides.Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin.Practical synthesis of 2-keto-3-deoxy-D-glycero-D-galactononulosonic acid (KDN).Highly stereoselective synthesis of alpha-D-mannopyranosyl phosphosugars.Silver-mediated allylic disulfide rearrangement for conjugation of thiols in protic media.Exploration of the Oxazolidinthione Protecting System for the Synthesis of Sialic Acid Glycosides.N6', N6''', and O4' Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity.Dihydro-3-(triphenylphosphoranylidene)-2,5-thiophendione: A Convenient Synthon for the Preparation of Substituted 1,4-Thiazepin-5-ones and Piperidinones via the Intermediacy of Thioacids.Further studies on cation clock reactions in glycosylation: observation of a configuration specific intramolecular sulfenyl transfer and isolation and characterization of a tricyclic acetal.Influence of 4'-O-Glycoside Constitution and Configuration on Ribosomal Selectivity of Paromomycin.Imposing the trans/gauche conformation on a sialic acid donor with a 5-N,7-O-oxazinanone group: effect on glycosylation stereoselectivity.A stable, commercially available sulfenyl chloride for the activation of thioglycosides in conjunction with silver trifluoromethanesulfonateAlternative synthesis and antibacterial evaluation of 1,5-dideoxy-1,5-imino-L-rhamnitol.Stereoselective C-glycoside formation with 2-O-benzyl-4,6-O-benzylidene protected 3-deoxy gluco- and mannopyranoside donors: comparison with O-glycoside formation.Dissecting the influence of oxazolidinones and cyclic carbonates in sialic acid chemistry.Triblock peptide and peptide thioester synthesis with reactivity-differentiated sulfonamides and peptidyl thioacids.Stereocontrolled synthesis of the D- and L-glycero-beta-D-manno-heptopyranosides and their 6-deoxy analogues. Synthesis of methyl alpha-l-rhamno-pyranosyl-(1-->3)-D-glycero-beta-D-manno-heptopyranosyl- (1-->3)-6-deoxy-glycero-beta-D-manno-heptopyran
P50
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P50
name
David Crich
@en
David Crich
@nl
type
label
David Crich
@en
David Crich
@nl
prefLabel
David Crich
@en
David Crich
@nl