about
Testing the role of predicted gene knockouts in human anthropometric trait variationLow-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibilitySystematic identification of trans eQTLs as putative drivers of known disease associationsGenome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohortsRare and low-frequency coding variants alter human adult heightCommon genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity.Genome-wide associations for birth weight and correlations with adult diseaseHuman aging is characterized by focused changes in gene expression and deregulation of alternative splicing.Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of associationGenetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes.Cell Specific eQTL Analysis without Sorting Cells.The transcriptional landscape of age in human peripheral blood.Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolismA genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistanceRecent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits.Common variants at 12q15 and 12q24 are associated with infant head circumference.Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.Parental diabetes and birthweight in 236 030 individuals in the UK biobank studyA genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.Tumor necrosis factor-alpha polymorphism at position -238 in preeclampsia.Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.Genetic origins of low birth weight.Quantifying the extent to which index event biases influence large genetic association studies.Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.Gene-obesogenic environment interactions in the UK Biobank study.Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes.Analysis with the exome array identifies multiple new independent variants in lipid lociCNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits.Exome-wide association study of plasma lipids in >300,000 individuals.Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion.A genetic variant in the seed region of miR-4513 shows pleiotropic effects on lipid and glucose homeostasis, blood pressure, and coronary artery disease.Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure.Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.Functional characterisation of ADIPOQ variants using individuals recruited by genotype.
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P50
name
Hanieh Yaghootkar
@en
Hanieh Yaghootkar
@nl
type
label
Hanieh Yaghootkar
@en
Hanieh Yaghootkar
@nl
prefLabel
Hanieh Yaghootkar
@en
Hanieh Yaghootkar
@nl