about
The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activityThe Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infectionApplications of microbial cytochrome P450 enzymes in biotechnology and synthetic biologyKinetic and structural basis of reactivity of pentaerythritol tetranitrate reductase with NADPH, 2-cyclohexenone, nitroesters, and nitroaromatic explosivesNovel haem co-ordination variants of flavocytochrome P450BM3Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGENThe structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathwayDNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosisBiophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactionsExpression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megateriumStructural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1Expression, purification and characterisation of a Bacillus subtilis ferredoxin: a potential electron transfer donor to cytochrome P450 BioI.Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis.Identification and characterization of the terminal enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located sirohydrochlorin ferrochelatase containing a 2FE-2S center.Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.Internal electron transfer in multi-site redox enzymes is accessed by laser excitation of thiouredopyrene-3,6,8-trisulfonate (TUPS).Characterisation of PduS, the pdu metabolosome corrin reductase, and evidence of substructural organisation within the bacterial microcompartment.Formation of transient oxygen complexes of cytochrome p450 BM3 and nitric oxide synthase under high pressure.The preponderance of P450s in the Mycobacterium tuberculosis genome.Flavocytochrome P450 BM3 and the origin of CYP102 fusion species.Bacterial flavodoxins support nitric oxide production by Bacillus subtilis nitric-oxide synthase.Biochemical and structural insights into bacterial organelle form and biogenesis.A novel intermediate in the reaction of seleno CYP119 with m-chloroperbenzoic acidThe TB structural genomics consortium: providing a structural foundation for drug discovery.Biofragments: an approach towards predicting protein function using biologically related fragments and its application to Mycobacterium tuberculosis CYP126.Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum.Flavoenzyme catalysed oxidation of amines: roles for flavin and protein-based radicals.Cytochrome P450s: creating novel ligand sets.Cytochrome P450--redox partner fusion enzymes.Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes.What makes a P450 tick?Overview on theoretical studies discriminating the two-oxidant versus two-state-reactivity models for substrate monoxygenation by cytochrome P450 enzymes.The pH dependence of kinetic isotope effects in monoamine oxidase A indicates stabilization of the neutral amine in the enzyme-substrate complex.Roles of key active-site residues in flavocytochrome P450 BM3Biological diversity of cytochrome P450 redox partner systems.Strength of axial water ligation in substrate-free cytochrome P450s is isoform dependent.Drug targeting of heme proteins in Mycobacterium tuberculosis.An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex.Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors.
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
A W Munro
@en
A W Munro
@nl
type
label
A W Munro
@en
A W Munro
@nl
prefLabel
A W Munro
@en
A W Munro
@nl
P108
P106
P108
P31
P496
0000-0002-4642-180X