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Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expressionMouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathwaySexually dimorphic expression of secreted frizzled-related (SFRP) genes in the developing mouse Müllerian ductLIMaS: the JAVA-based application and database for microarray experiment tracking.ENU mutagenesis as a tool for understanding lung development and disease.Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice.A novel mouse Fgfr2 mutant, hobbyhorse (hob), exhibits complete XY gonadal sex reversal.Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1.Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determinationSingle primer amplification (SPA) of cDNA for microarray expression analysis.SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasiaScribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung.Using DNA microarrays.Characterising novel pathways in testis determination using mouse genetics.Understanding sex determination in the mouse: genetics, epigenetics and the story of mutual antagonisms.The Gonadal Supporting Cell Lineage and Mammalian Sex Determination: The Differentiation of Sertoli and Granulosa Cells.Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination.Molecular phenotyping of the mouse ky mutant reveals UCP1 upregulation at the neuromuscular junctions of dystrophic soleus muscle.Screening for novel ENU-induced rhythm, entrainment and activity mutants.Genetic Disruption of 21-Hydroxylase in Zebrafish Causes Interrenal Hyperplasia.Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal.Assisted reproductive technologies to prevent human mitochondrial disease transmission.The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region.Zic2 is required for neural crest formation and hindbrain patterning during mouse development.Rationality: Science is not bad faith.Corrigendum: Assisted reproductive technologies to prevent human mitochondrial disease transmission.Sexually dimorphic expression of Gata-2 during mouse gonad development.Editing mammalian genomes: ethical considerations.ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.Characterisation and use of a functional Gadd45g bacterial artificial chromosomeGENETICS IN ENDOCRINOLOGY: Approaches to molecular genetic diagnosis in the management of differences/disorders of sex development (DSD): position paper of EU COST Action BM 1303 "DSDnet"Corrigendum: Assisted reproductive technologies to prevent human mitochondrial disease transmissionCRISPR-Cas9-Mediated Mutagenesis: Mind the Gap?Carry on editingFearful old world? A commentary on the Second International Summit on human genome editingMale mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weightProtection Against XY Gonadal Sex Reversal by a Variant Region on Mouse Chromosome 13Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndromeDissecting Cell Lineage Specification and Sex Fate Determination in Gonadal Somatic Cells Using Single-Cell TranscriptomicsAddressing gaps in care of people with conditions affecting sex development and maturation
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description
researcher
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wetenschapper
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name
A Greenfield
@en
A Greenfield
@nl
type
label
A Greenfield
@en
A Greenfield
@nl
prefLabel
A Greenfield
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A Greenfield
@nl
P106
P31
P496
0000-0002-1477-1776