about
Current progress on esterases: from molecular structure to functionHepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liverVirtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on IrinotecAssociation of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patientsThe critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages.Key structural features of ligands for activation of human pregnane X receptor.Analysis of a child who developed abnormal neuropsychiatric symptoms after administration of oseltamivir: a case report.Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques.Functional analysis of carboxylesterase in human induced pluripotent stem cell-derived enterocytes.Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor.Dexamethasone-induced methylprednisolone hemisuccinate hydrolase: its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma.Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic aFunctional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites.Evidence for the involvement of a pulmonary first-pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration.Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo.Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy.Gly143Glu polymorphism of the human carboxylesterase1 gene in an Asian population.Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver.Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes.Synthesis of a new class of camptothecin derivatives, the long-chain fatty acid esters of 10-hydroxycamptothecin, as a potent prodrug candidate, and their in vitro metabolic conversion by carboxylesterasesSpecies-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesteraseFawcettimine-related alkaloids from Lycopodium serratumDexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 geneAre non-human primates useful experimental animals for pre-clinical study?A new methodology for functionalization at the 3-position of indoles by a combination of boron Lewis acid with nitrilesSystematic identification and characterization of carboxylesterases in cynomolgus macaquesSynthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterasesChemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaquesDevelopment of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability StudiesSynthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesteraseStructure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases
P50
Q28214549-04AB4D54-1E79-46B2-99D8-795EA0801B35Q28589599-E131F7CA-1A52-44EF-BEA3-FA01D8CCA01EQ33875931-C10318C2-3072-445C-B2D6-DDE00F98F13BQ34026252-25014DAA-22D3-4EAA-B492-B6C4BC986160Q34143716-0500E8B5-3C29-45AC-A6CD-CAA0C3842EB0Q34308151-06B0F6EF-2B04-4EAD-8062-0AFD5B14B4CEQ35737905-D50FFB35-747B-4466-A6C8-62A1694DAD40Q35807865-85459373-52C5-4729-A033-533AD3ED58E8Q38712589-2D661A08-20E2-41DA-9258-3FB54038DCD4Q40440482-D628FE8E-8B18-46E6-A2B6-E3BC9110123DQ42041603-329AE59C-4C2E-4FDD-BB34-A11D11B82343Q43908947-3FA5A7BB-0713-444A-A621-E56176D29435Q44197890-C3B49F05-4A5E-4368-994F-6997611303EBQ44611073-B9606838-A66D-4EDF-8B35-B38DC0D090C4Q44619182-2A396123-FF78-487C-AB18-F456C559698AQ45086485-74D7B548-23E7-40E9-AB6D-5E2DFA0122CDQ45245081-78F678AF-064B-4E7F-A68D-4993D388A455Q46468315-96A4802C-A591-49F0-B210-893F4DB414E3Q49561565-7BA96421-8467-48FF-8606-3DB0278C9B4DQ55048878-91716C40-AEED-499B-B0C1-D62E9813053EQ77744045-47DC90EA-E8F9-48D6-B008-E7386E3B606BQ79257195-43BDC4FF-A5A7-45C6-A20A-557C5928B2CDQ80339197-1589583E-4D58-4686-8A8C-D9821DC2F90EQ83209885-81CF98FF-C936-4B8F-88DF-D71A9650724CQ84541532-6B5B8A0A-FC59-4CC8-9AC0-66C7E257040BQ85507852-2C1D3EA7-012C-4D72-9410-BA613CA52C15Q85638797-5A6D5BE6-F61C-40BC-A714-4A3B7798CA4FQ87047406-7151B31A-E915-4EF7-BB3F-4F51BFC920B7Q87954247-8CE10B30-FE45-49C2-AAF4-DDC653F35886Q88156864-1C573EB7-15EA-40B9-861D-66754BFAE832Q88516057-31931F4C-279C-4DC3-8057-962132ADA573Q92411056-1A2F4036-5813-41D2-854D-6A409888CB87Q92584519-E42F34A3-2014-42D9-8F1A-62313F1A106F
P50
description
researcher
@en
wetenschapper
@nl
name
M Hosokawa
@en
M Hosokawa
@nl
type
label
M Hosokawa
@en
M Hosokawa
@nl
prefLabel
M Hosokawa
@en
M Hosokawa
@nl
P106
P31
P496
0000-0001-5750-6369