about
Assay Establishment and Validation of a High-Throughput Screening Platform for Three-Dimensional Patient-Derived Colon Cancer Organoid CulturesDNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.The role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells.Ras-mediated deregulation of the circadian clock in cancer.The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFNgamma-induced cell death in human ovarian carcinoma cells.Uncoupling of EGFR-RAS signaling and nuclear localization of YBX1 in colorectal cancerMolecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.Network quantification of EGFR signaling unveils potential for targeted combination therapy.Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancerAtypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer.Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells.Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity.Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D culturesEpigenetic regulation of Amphiregulin and Epiregulin in colorectal cancerDiscovery and Validation of Novel Biomarkers for Detection of Epithelial Ovarian CancerVIST - a Variant-Information Search Tool for precision oncology
P50
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P50
description
researcher
@en
name
Reinhold Schäfer
@en
Reinhold Schäfer
@nl
type
label
Reinhold Schäfer
@en
Reinhold Schäfer
@nl
prefLabel
Reinhold Schäfer
@en
Reinhold Schäfer
@nl
P106
P108
P31
P496
0000-0001-7952-2124